| Name | cytochrome P450 2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | α-chlorohydrin |
|---|---|
| CAS | 3-chloro-1,2-propanediol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9192205 | Stott I, Murthy A, Robinson A, Thomas NW, Fry JR: Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1,3-dichloro- and selectively inhibits CYP2E1 activity in the rat. Hum Exp Toxicol. 1997 May;16(5):262-6. |
3(0,0,0,3) | Details |
| 12183104 | Forkert PG, Lash LH, Nadeau V, Tardif R, Simmonds A: Metabolism and toxicity of trichloroethylene in epididymis and testis. . Toxicol Appl Pharmacol. 2002 Aug 1;182(3):244-54. Cytochrome P450 2E1 (CYP2E1), an enzyme involved in TCE metabolism, was localized in the epididymal epithelium and testicular Leydig cells, and was found at higher levels in the former than the latter. |
3(0,0,0,3) | Details |
| 10528996 | Hammond AH, Fry JR: Effect of cyanamide on toxicity and depletion in rat hepatocyte cultures: differences between two dichloropropanol isomers. Chem Biol Interact. 1999 Sep 30;122(2):107-15. Induction of CYP2E1 also potentiated the toxicity of 2,3-dichloropropanol, and in these cultures cyanamide pre-treatment significantly increased both toxicity and depletion. |
2(0,0,0,2) | Details |
| 10418953 | Fry JR, Sinclair D, Piper CH, Townsend SL, Thomas NW: Depression of content, elevation of CYP2E1-dependent activation, and the principal determinant of the fasting-mediated enhancement of 1,3-dichloro- hepatotoxicity in the rat. Food Chem Toxicol. 1999 Apr;37(4):351-5. |
2(0,0,0,2) | Details |
| 9242585 | Green T, Mainwaring GW, Foster JR: Trichloroethylene-induced mouse lung tumors: studies of the mode of action and comparisons between species. Fundam Appl Toxicol. 1997 Jun;37(2):125-30. Immunolocalization of cytochrome P450IIE1 in lung sections revealed high concentrations in mouse lung Clara cells with lesser amounts in type II cells. |
1(0,0,0,1) | Details |
| 8825194 | Ni YC, Wong TY, Lloyd RV, Heinze TM, Shelton S, Casciano D, Kadlubar FF, Fu PP: Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism. Drug Metab Dispos. 1996 Jan;24(1):81-90. Thus, our study suggests that cytochrome P450 is the enzyme catalyzing the metabolic activation of CH and its metabolites (TCA and TCE) leading to lipid peroxidation, and that CYP2E1 may be the major isozyme responsible. |
1(0,0,0,1) | Details |
| 16882532 | Bronley-DeLancey A, McMillan DC, McMillan JM, Jollow DJ, Mohr LC, Hoel DG: Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol. Environ Health Perspect. 2006 Aug;114(8):1237-42. Chloral hydrate (CH) is the major metabolite of TCE formed in the liver by cytochrome P450 2E1. |
1(0,0,0,1) | Details |