| Name | alcohol dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | ADH; alcohol dehydrogenase; alcohol dehydrogenases |
| Name | α-chlorohydrin |
|---|---|
| CAS | 3-chloro-1,2-propanediol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3550385 | Cunningham PR, Clark DP: The use of suicide substrates to select mutants of Escherichia coli lacking enzymes of fermentation. Mol Gen Genet. 1986 Dec;205(3):487-93. Most also lacked the associated fermentative enzyme alcohol dehydrogenase. |
3(0,0,0,3) | Details |
| 20056735 | Chen YT, Liao JW, Hung DZ: Protective effects of fomepizole on 2-chloroethanol toxicity. Hum Exp Toxicol. 2010 Jun;29(6):507-12. Epub 2010 Jan 7. Alcohol dehydrogenase and were hypothesized to be important in the metabolism of 2-CE. |
2(0,0,0,2) | Details |
| 6353674 | Sharkawi M, De Saint Blanquat G, Elfassy B: Inhibition of alcohol dehydrogenase by chloral hydrate and trichloroethanol: possible role in the chloral hydrate- interaction. Toxicol Lett. 1983 Jul;17(3-4):321-8. |
2(0,0,0,2) | Details |
| 9881930 | Faci A, Plaa GL, Sharkawi M: Chloral hydrate enhances -induced inhibition of oxidation in mice. Toxicology. 1998 Nov 2;131(1):1-7. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. |
1(0,0,0,1) | Details |
| 17321661 | Skamarauskas J, Carter W, Fowler M, Madjd A, Lister T, Mavroudis G, Ray DE: The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation. Toxicology. 2007 Apr 11;232(3):268-76. Epub 2007 Jan 21. We were able to show that 3-CPD is a substrate for glutathione-S-transferase and also that, after bioactivation by alcohol dehydrogenase, it generates an irreversible inhibitor of glutathione reductase. |
1(0,0,0,1) | Details |
| 1913979 | Hahn H, Eder E, Deininger C: Genotoxicity of 1,3-dichloro- in the SOS chromotest and in the Ames test. Chem Biol Interact. 1991;80(1):73-88. We have investigated whether alcohol dehydrogenase (ADH) catalysed activation to the highly mutagenic and carcinogenic 1,3-dichloroacetone or formation of epichlorohydrin or other genotoxic compounds play a role for mutagenicity and genotoxicity. |
1(0,0,0,1) | Details |
| 2593173 | Larson JL, Bull RJ: Effect of on the metabolism of trichloroethylene. J Toxicol Environ Health. 1989;28(4):395-406. CH can either be oxidized by chloral hydrate dehydrogenase to trichloroacetic acid (TCA) or reduced by alcohol dehydrogenase to trichloroethanol (TCEtOH). |
1(0,0,0,1) | Details |