Protein Information

Name glucose 6 phosphatase
Synonyms G 6 Pase; G6PC; G6PT; G6Pase; GSD1a; Glucose 6 phosphatase; Glucose 6 phosphatase hydrolytic subunit; G6Pases…

Compound Information

Name α-chlorohydrin
CAS 3-chloro-1,2-propanediol

Reference List

PubMed Abstract RScore(About this table)
926208 Feuer G, Balazs T, Farkus R, Ilyas MS: Effect of 2-chloroethanol on hepatic microsomal enzymes in the rat. J Toxicol Environ Health. 1977 Oct;3(3):569-76.


A significant reduction in activities of drug-metabolizing enzymes (aminopyrine N-demethylase, coumarin 3-hydroxylase) and a marked decrease of glucose 6-phosphatase were seen in both sexes given dose levels of 20 mg/kg sc daily for 7 days.
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6265379 Kaur S, Guraya SS: Effect of low doses of alpha chlorohydrin on the enzymes of glycolytic and phosphogluconate pathways in the rat testis and epididymis. Int J Androl. 1981 Apr;4(2):196-207.


LDH, ADH and glucose-6-phosphatase were also studied histochemically to show that the drug affects the glycolytic enzymes of epididymal cells and various testicular cell types of testis.
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2994252 Buben JA, O'Flaherty EJ: Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study. Toxicol Appl Pharmacol. 1985 Mar 30;78(1):105-22.


Four parameters of hepatotoxicity were assessed: liver weight, triglycerides, glucose-6-phosphatase (G6P) activity, and SGPT activity.
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