Protein Information

Name TRAAK
Synonyms 2P domain potassium channel; KCNK 4; KCNK4; Potassium channel subfamily K member 4; Potassium inwardly rectifying channel subfamily K member 4; TRAAK; TRAAK 1; TRAAK1…

Compound Information

Name α-chlorohydrin
CAS 3-chloro-1,2-propanediol

Reference List

PubMed Abstract RScore(About this table)
19955488 Parelkar NK, Silswal N, Jansen K, Vaughn J, Bryan RM Jr, Andresen J: 2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10. Epub 2009 Dec 2.


Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] is a sedative/hypnotic that increases cerebral blood flow (CBF), and its active metabolite 2,2,2-trichloroethanol (TCE) is an agonist for the nonclassical two-pore domain K (+) (K (2P)) channels TREK-1 and TRAAK.		 4(0,0,0,4) Details
14996553 Harinath S, Sikdar SK: Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels. Neuropharmacology. 2004 Apr;46(5):750-60.

 3(0,0,0,3) Details