Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name α-chlorohydrin
CAS 3-chloro-1,2-propanediol

Reference List

PubMed Abstract RScore(About this table)
1438041 Onks DL, Robertson AF, Brodersen R: The effect of chloral hydrate and its metabolites, trichloroethanol and trichloroacetic acid, on bilirubin-albumin binding. Pharmacol Toxicol. 1992 Sep;71(3 Pt 1):196-7.

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11834892 Solt K, Johansson JS: Binding of the active metabolite of chloral hydrate, 2,2,2-trichloroethanol, to serum albumin demonstrated using tryptophan fluorescence quenching. Pharmacology. 2002;64(3):152-9.


Tryptophan fluorescence quenching has been used previously to show that halothane and chloroform bind saturably to serum albumin, and a similar approach is used here to demonstrate that TCE also binds to albumin.
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11869834 Mensing T, Welge P, Voss B, Fels LM, Fricke HH, Bruning T, Wilhelm M: Renal toxicity after chronic inhalation exposure of rats to trichloroethylene. Toxicol Lett. 2002 Mar 10;128(1-3):243-7.


Specific parameters related to the renal damage were determined in urine [biomarker for glomerular damage: high molecular weight proteins (HMW), albumin (ALB); for proximal tubular damage: N-acetyl-beta-D-glucosaminidase (NAG), low-molecular-weight-proteins (LMW)].
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11201665 De Smet K, Bruning T, Blaszkewicz M, Bolt HM, Vercruysse A, Rogiers V: Biotransformation of trichloroethylene in collagen gel sandwich cultures of rat hepatocytes. Arch Toxicol. 2000 Dec;74(10):587-92.


Endpoints studied were albumin secretion and the cytochrome P450 (CYP)-dependent enzymatic activities ethoxyresorufin O-deethylase (EROD), pentoxyresorufin O-depentylase (PROD) and N-nitrosodimethylamine demethylase (NDMA).
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