| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | α-chlorohydrin |
|---|---|
| CAS | 3-chloro-1,2-propanediol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17321661 | Skamarauskas J, Carter W, Fowler M, Madjd A, Lister T, Mavroudis G, Ray DE: The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation. Toxicology. 2007 Apr 11;232(3):268-76. Epub 2007 Jan 21. We were able to show that 3-CPD is a substrate for glutathione-S-transferase and also that, after bioactivation by alcohol dehydrogenase, it generates an irreversible inhibitor of glutathione reductase. |
1(0,0,0,1) | Details |
| 9810144 | Katoh T, Haratake J, Nakano S, Kikuchi M, Yoshikawa M, Arashidani K: Dose-dependent effects of dichloropropanol on liver histology and lipid peroxidation in rats. Ind Health. 1998 Oct;36(4):318-23. Fresh liver tissues from further 4 control and 4 experimental rats sacrificed 6 hours after the injection of 20% and 1 x LD50 of DC2P were homogenized and subjected to evaluate lipid peroxidation, glutathione S-transferase activity and contents in the liver. |
2(0,0,0,2) | Details |
| 12235957 | Kuroda Y, Fueta Y, Kohshi K, Nakao H, Imai H, Katoh T: [Toxicity of dichloropropanols]. J UOEH. 2002 Sep 1;24(3):271-80. Hepatic malondialdehyde level was significantly increased, and associated with a decrease in liver glutathione S-transferase activity and content. |
1(0,0,0,1) | Details |
| 3966241 | Storer RD, Conolly RB: An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane. Toxicol Appl Pharmacol. 1985 Jan;77(1):36-46. In vitro studies have demonstrated that two different metabolic pathways, conjugation mediated by the glutathione S-transferases and microsomal oxidation, may be involved in the genotoxicity and carcinogenicity of 1,2-dichloroethane (DCE). |
1(0,0,0,1) | Details |