| Name | glycolytic enzyme |
|---|---|
| Synonyms | Brain form hexokinase; HK1; Glycolytic enzyme; HK I; HK1 sa; HK1 sb; HK1 ta; HK1 tb… |
| Name | α-chlorohydrin |
|---|---|
| CAS | 3-chloro-1,2-propanediol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11330647 | Bone W, Jones AR, Morin C, Nieschlag E, Cooper TG: Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro. J Androl. 2001 May-Jun;22(3):464-70. |
3(0,0,0,3) | Details |
| 6265379 | Kaur S, Guraya SS: Effect of low doses of alpha chlorohydrin on the enzymes of glycolytic and phosphogluconate pathways in the rat testis and epididymis. Int J Androl. 1981 Apr;4(2):196-207. A biochemical study has been made of the effects of low doses of alpha chlorohydrin on all the glycolytic enzymes and two key enzymes of phosphogluconate pathway i.e. glucose-6-phosphate dehydrogenase (G-6-PDH) and 6-phosphogluconate dehydrogenase (6-PGDH) of rat testis and epididymis. |
3(0,0,0,3) | Details |
| 11012786 | Bone W, Cooper TG: In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, alpha-chlorohydrin and 1-chloro-3-hydroxypropanone. Int J Androl. 2000 Oct;23(5):284-93. |
2(0,0,0,2) | Details |
| 21325689 | Terrell KA, Wildt DE, Anthony NM, Bavister BD, Leibo SP, Penfold LM, Marker LL, Crosier AE: Glycolytic enzyme activity is essential for domestic cat (Felis catus) and cheetah (Acinonyx jubatus) sperm motility and viability in a sugar-free medium. Biol Reprod. 2011 Jun;84(6):1198-206. Epub 2011 Feb 16. |
2(0,0,0,2) | Details |
| 16407453 | Ford WC: Glycolysis and sperm motility: does a spoonful of sugar help the flagellum go round?. Hum Reprod Update. 2006 May-Jun;12(3):269-74. Epub 2006 Jan 11. Glycolytic enzymes bound to the fibrous sheath could provide energy along the flagellum at the point it is required. |
1(0,0,0,1) | Details |
| 4018888 | Jones AR, du Toit JI: The anti-glycolytic action of (S)-alpha-chlorohydrin on epididymal bovine spermatozoa in vitro. Int J Androl. 1985 Apr;8(2):119-27. It is proposed that the action of (S)-alpha-chlorohydrin in bovine spermatozoa is similar to that observed in the spermatozoa of other species in being a two-stage process; first, its oxidation to (S)-3-chlorolactaldehyde, and then inhibition of the glycolytic enzyme by this metabolite. |
1(0,0,0,1) | Details |
| 16322075 | Nemeti B, Csanaky I, Gregus Z: Effect of an inactivator of glyceraldehyde-3-phosphate dehydrogenase, a fortuitous arsenate reductase, on disposition of arsenate in rats. Toxicol Sci. 2006 Mar;90(1):49-60. Epub 2005 Dec 1. Recently, we have demonstrated that the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the reduction of AsV in the presence of yet the role of GAPDH in AsV reduction in vivo is unknown. |
1(0,0,0,1) | Details |
| 483861 | Jones AR, Mashford PM, Murcott C: The metabolism of 3-amino-1-chloropropan-2-ol in relation to its antifertility activity in male rats. Xenobiotica. 1979 Apr;9(4):253-61. A difference in metabolic rate or route of the isomers may account for their differing physiological activities. 4. (+)- and (-)-aminochloropropanol exhibited identical in vitro inhibitory activities on the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase, and were substrates for monoamine oxidase to equivalent extents. |
1(0,0,0,1) | Details |
| 9702787 | Sheline CT, Choi DW: Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomerase. Neurobiol Dis. 1998 Jul;5(1):47-54. -containing proteins expressed in the CAG repeat diseases Huntington's disease and dentatorubralpallidoluyisian atrophy have recently been suggested to inhibit the key glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). |
1(0,0,0,1) | Details |
| 7277334 | Ford WC, Harrison A, Waites GM: Effects of 6-chloro-6-deoxysugars on oxidation in rat spermatozoa. . J Reprod Fertil. 1981 Sep;63(1):67-73. The activities of the glycolytic enzymes were greatly in excess of the observed flux through the pathway and high concentrations of and triose accumulated in rat spermatozoa incubated with 2 mM- |
1(0,0,0,1) | Details |
| 629780 | Brown-Woodman PD, Mohri H, Mohri T, Suter D, White IG: Mode of action of alpha-chlorohydrin as a male anti-fertility agent. Biochem J. 1978 Jan 15;170(1):23-37. Measurement of intermediates and glycolytic enzymes in ejaculated spermatozoa before, during and after injection of rams with alpha-chlorohydrin (25mg/kg body wt.) confirmed a severe block in glycolysis in vivo at the site of triose conversion into within 24h of the first injection. |
1(0,0,0,1) | Details |