Protein Information

Name Potassium channel (protein family or complex)
Synonyms Potassium channel

Compound Information

Name sodium cyanide
CAS sodium cyanide (Na(CN))

Reference List

PubMed Abstract RScore(About this table)
9099818 Wind T, Prehn JH, Peruche B, Krieglstein J: Activation of ATP-sensitive potassium channels decreases neuronal injury caused by chemical hypoxia. Brain Res. 1997 Mar 21;751(2):295-9.


This process can be therapeutically mimicked by treatment with potassium channel openers.
4(0,0,0,4) Details
12911616 Lee AL, Dumas TC, Tarapore PE, Webster BR, Ho DY, Kaufer D, Sapolsky RM: Potassium channel gene therapy can prevent neuron death resulting from necrotic and apoptotic insults. J Neurochem. 2003 Sep;86(5):1079-88.

We found that SK2 or Kv1.1 protected not only against kainate or glutamate excitotoxicity but also increased survival after sodium cyanide or staurosporine.
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17720390 Al-Dadah AS, Voeller RK, Schuessler RB, Damiano RJ Jr, Lawton JS: Maintenance of myocyte volume homeostasis during stress by diazoxide is cardioprotective. Ann Thorac Surg. 2007 Sep;84(3):857-62.

BACKGROUND: We previously demonstrated that myocyte swelling and reduced contractility secondary to hyperkalemic cardioplegia and hyposmotic stress are attenuated by the addition of diazoxide, an adenosine triphosphate-sensitive potassium channel (K (ATP)) opener.
Test solutions included (1) Tyrode's control, (2) a metabolic inhibition solution containing sodium cyanide and 2-deoxyglucose, (3) metabolic inhibition plus diazoxide, (4) metabolic inhibition plus diazoxide plus HMR1098 (a sarcolemmal K (ATP)-channel blocker), or (5) metabolic inhibition plus diazoxide plus 5-hydroxydeconoate (a mitochondrial K (ATP)-channel blocker).
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8834104 Chao KF, Liu SH, Lin-Shiau SY: Suppression of potassium currents by cyanide on the mouse motor nerve terminals. Neurosci Lett. 1996 Jan 19;203(2):105-8.


NaCN at low concentrations markedly depressed the potassium currents in the motor nerve terminal of mouse triangularis sterni neuromuscular junction pretreated with potassium channel blockers 4-aminopyridine (4-AP), tetraethylammonium (TEA) or glucose-free medium.
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11953139 Zhang X, Lu G: [Effect of brain extract of hypoxic preconditioned mice on activity of ATP sensitive potassium channel in hippocampal neurons]. Zhonghua Yi Xue Za Zhi. 2002 Jan 25;82(2):108-10.

RESULTS: Ik was significantly increased by addition of sodium cyanide (NaCN) (1448--> 2381 pA) and the increase was significantly inhibited (2381--> 1725 pA) by application of glibenclamide (GLI).
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