Protein Information

Name calmodulin
Synonyms CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3…

Compound Information

Name sodium cyanide
CAS sodium cyanide (Na(CN))

Reference List

PubMed Abstract RScore(About this table)
9748253 Xia Y, Tsai AL, Berka V, Zweier JL: Superoxide generation from endothelial nitric-oxide synthase. J Biol Chem. 1998 Oct 2;273(40):25804-8.


A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process..
2(0,0,0,2) Details
11287127 Porasuphatana S, Tsai P, Pou S, Rosen GM: Involvement of the perferryl complex of nitric oxide synthase in the catalysis of secondary free radical formation. Biochim Biophys Acta. 2001 Apr 3;1526(1):95-104.

The generation of CH (3)*CHOH by NOS I was found to be Ca (2+)/calmodulin dependent.
Formation of CH (3)*CHOH was inhibited by substituting D-arginine for L-arginine, or inclusion of the NOS inhibitors N (G)-nitro-L-arginine methyl ester, N (G)-monomethyl-L-arginine and the heme blocker, sodium cyanide.
2(0,0,0,2) Details
6219742 Scully SP, Segel GB, Lichtman MA: Plasma membrane vesicles prepared from unadhered monocytes: characterization of calcium transport and the calcium ATPase. Cell Calcium. 1982 Dec;3(6):515-30.

Monocyte plasma membranes that were stripped of endogenous calmodulin by EGTA treatment showed a reduced level of calcium uptake and calcium ATPase activity.
The ionophore A23187 completely inhibited calcium accumulation while 5 mM sodium cyanide and 10 microM ouabain had no effect.
2(0,0,0,2) Details
6097546 Smith RJ, Iden SS, Bowman BJ: Activation of the human neutrophil secretory process with 5 (S),12 (R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid. Inflammation. 1984 Dec;8(4):365-84.

The calmodulin antagonist, trifluoperazine (TFP), and the intracellular calcium antagonist, 8-(N,N-diethylamino)-octyl-(3,4,5-trimethoxy) benzoate hydrochloride (TMB-8), caused a dose-related inhibition of enzyme release from LTB4-stimulated neutrophils.
Sodium cyanide was inactive.
1(0,0,0,1) Details
6872358 Smith RJ, Bowman BJ, Iden SS: Characteristics of 1-O-hexadecyl- and 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine-stimulated granule enzyme release from human neutrophils. Clin Immunol Immunopathol. 1983 Jul;28(1):13-28.

Trifluoperazine, an inhibitor of calmodulin, caused a dose-related suppression of C18-AGEPC-induced degranulation.
Sodium cyanide was inactive.
1(0,0,0,1) Details
8382363 Hanaoka K, Sakai O, Imai M, Yoshitomi K: Mechanisms of calcium transport across the basolateral membrane of the rabbit cortical thick ascending limb of Henle's loop. Pflugers Arch. 1993 Jan;422(4):339-46.


Calmodulin inhibitors (trifluoperazine or W-7) increased [Ca2+] i.
1(0,0,0,1) Details
2434190 Edstrom A, Ekstrom P, Kanje M, Sjoberg J: The use of the regenerating frog sciatic nerve for pharmacological studies of orthograde and retrograde axonal transport. Brain Res. 1987 Jan 13;401(1):34-42.


Compound 48/80 (50 micrograms/ml), the most specific calmodulin inhibitor so far described, inhibited the transport along the same part of the nerve.
1(0,0,0,1) Details