| Name | Cytochrome c oxidase (protein family or complex) |
|---|---|
| Synonyms | COX; cytochrome c oxidase; cytochrome c oxidases |
| Name | sodium cyanide |
|---|---|
| CAS | sodium cyanide (Na(CN)) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9309676 | Loffler M, Jockel J, Schuster G, Becker C: Dihydroorotat- oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Mol Cell Biochem. 1997 Sep;174(1-2):125-9. The application of known enzyme inhibitors Brequinar and Leflunomide for DHODH and sodium cyanide for cytochrome c oxidase verified the specificity of the activity tests used. |
32(0,1,1,2) | Details |
| 19278021 | Song C, Scharf ME: Mitochondrial impacts of insecticidal esters in insecticide-resistant and insecticide-susceptible Drosophila melanogaster. Pest Manag Sci. 2009 Jun;65(6):697-703. RESULTS: In initial studies investigating inhibition of mitochondrial cytochrome c oxidase, two proven insecticidal materials (hydramethylnon and sodium cyanide) caused significant inhibition. |
31(0,1,1,1) | Details |
| 2225377 | Beanlands RS, Dawood F, Wen WH, McLaughlin PR, Butany J, D'Amati G, Liu PP: Are the kinetics of technetium-99m methoxyisobutyl isonitrile affected by cell metabolism and viability?. Circulation. 1990 Nov;82(5):1802-14. The hearts were studied after inducing irreversible damage by cytochrome c oxidase inhibitor sodium cyanide (n = 8) or sarcolemmal membrane detergent Triton X-100 (n = 8). |
31(0,1,1,1) | Details |
| 6268605 | Stade S, Brambl R: Mitochondrial biogenesis during fungal spore germination: respiration and cytochrome c oxidase in Neurospora crassa. J Bacteriol. 1981 Sep;147(3):757-67. |
5(0,0,0,5) | Details |
| 12913298 | Sugio T, Fujii M, Takeuchi F, Negishi A, Maeda T, Kamimura K: Volatilization of mercury by an iron oxidation enzyme system in a highly mercury-resistant Acidithiobacillus ferrooxidans strain MON-1. Biosci Biotechnol Biochem. 2003 Jul;67(7):1537-44. oxidizing activities, 2,3,5,6-tetramethyl-p-phenylenediamine (TMPD) oxidizing activities and cytochrome c oxidase activities of strains SUG 2-2 and MON-1 were 26.3 and 41.9 microl O2 uptake/mg/min, 15.6 and 25.0 microl O2 uptake/mg/min, and 2.1 and 6.1 mU/mg, respectively. Mercury volatilized by the Fe (2+)-dependent mercury volatilization enzyme system of strain MON-1 was strongly inhibited by 1.0 mM sodium cyanide, but was not by 50 nM rotenone, 5 microM 2-n-heptyl-4--quinoline-N-oxide (HQNO), 0.5 microM antimycin A, or 0.5 microM myxothiazol, indicating that cytochrome c oxidase plays a crucial role in mercury volatilization of strain MON-1 in the presence of Fe2+. |
2(0,0,0,2) | Details |
| 14559295 | Haritos VS, Dojchinov G: Cytochrome c oxidase inhibition in the rice weevil Sitophilus oryzae (L.) by the toxic metabolite of volatile alkyl formates. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Oct;136(2):135-43. When tested against isolated mitochondria from S. oryzae, alkyl esters, and salts were not inhibitory towards cytochrome c oxidase (EC 1.9.3.1), but sodium cyanide and were inhibitory with IC (50) values of 0.0015 mM and 59 mM, respectively. |
2(0,0,0,2) | Details |
| 16566602 | Fabian M, Jancura D, Bona M, Musatov A, Baran M, Palmer G: Influence of reduction of heme a and Cu (A) on the oxidized catalytic center of cytochrome c oxidase: insight from organic solvents. Biochemistry. 2006 Apr 4;45(13):4277-83. |
2(0,0,0,2) | Details |
| 9399580 | Sakamoto J, Handa Y, Sone N: A novel cytochrome b (o/a) 3-type oxidase from Bacillus stearothermophilus catalyzes cytochrome c-551 oxidation. J Biochem. 1997 Oct;122(4):764-71. The oxidase activity was enhanced by the presence of salts and inhibited by sodium cyanide with a Ki value of 19 microM. Gram-positive thermophilic Bacillus species contain cytochrome caa3-type cytochrome c oxidase as their main terminal oxidase in the respiratory chain. |
1(0,0,0,1) | Details |
| 10551842 | Azarkina N, Siletsky S, Borisov V, von Wachenfeldt C, Hederstedt L, Konstantinov AA: A cytochrome bb'-type oxidase in Bacillus subtilis strain 168. J Biol Chem. 1999 Nov 12;274(46):32810-7. The aerobic respiratory system of Bacillus subtilis 168 is known to contain three terminal oxidases: cytochrome caa (3), which is a cytochrome c oxidase, and cytochrome aa (3) and bd, which are oxidases. |
1(0,0,0,1) | Details |
| 1309979 | Centeno JA: Evidence of dithionite contribution to the low-frequency resonance Raman spectrum of reduced and mixed-valence cytochrome c oxidase. Arch Biochem Biophys. 1992 Feb 1;292(2):624-8. |
1(0,0,0,1) | Details |
| 12153998 | Streller T, Huckstorf C, Pfeiffer C, Acker H: Unusual cytochrome a592 with low PO2 affinity correlates as putative sensor with rat carotid body chemoreceptor discharge. FASEB J. 2002 Aug;16(10):1277-9. Epub 2002 Jun 21. Light-absorption spectra and afferent chemoreceptor discharge were simultaneously recorded on superfused rat carotid bodies (CBs) under the influence of cytochrome a3-CuB ligands (O2, CN-, CO) in order to identify the primary mitochondrial cytochrome c oxidase (CCO) sensor. The spectral weight of cytochrome a592 decreased significantly starting at high PO2 (100 mm Hg) and low sodium cyanide (CN-, 10 mM) accompanied by increasing phasic peak discharge. |
1(0,0,0,1) | Details |
| 19601395 | David M, Ramesh H, Deshpande SP, Chebbi SG, Krishnamurthy G: Respiratory distress and behavioral changes induced by sodium cyanide in the fresh water TELEOST, Cyprinus carpio (Linnaeus). J Basic Clin Physiol Pharmacol. 2009;20(1):55-65. Cyprinus carpio in toxic media exhibited irregular, erratic, and darting swimming movements, hyperexcitability, loss of equilibrium, and sinking to the bottom, which might be due to inhibition of cytochrome c oxidase activity and decreased blood pH. |
1(0,0,0,1) | Details |
| 9571175 | Stubauer G, Giuffre A, Brunori M, Sarti P: Cytochrome c oxidase does not catalyze the anaerobic reduction of NO. Biochem Biophys Res Commun. 1998 Apr 17;245(2):459-65. A possible role of reduced cytochrome c oxidase in the metabolism of (NO) has been examined with amperometric and stopped-flow photometric techniques. |
1(0,0,0,1) | Details |