| Name | cytochrome c |
|---|---|
| Synonyms | CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs |
| Name | sodium cyanide |
|---|---|
| CAS | sodium cyanide (Na(CN)) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 36133 | Andersson T, Thulin E, Forsen S: Ion binding to cytochrome c studied by nuclear magnetic quadrupole relaxation. Biochemistry. 1979 Jun 12;18(12):2487-93. The enhancement of the 35Cl- transverse relaxation rate on binding of ions to oxidized and reduced cytochrome c has been studied under conditions of variable concentration, temperature, pH, iron hexacyanide, and sodium cyanide concentration. |
32(0,1,1,2) | Details |
| 15924423 | Batthyany C, Souza JM, Duran R, Cassina A, Cervenansky C, Radi R: Time course and site (s) of cytochrome c nitration by Biochemistry. 2005 Jun 7;44(22):8038-46. |
13(0,0,0,13) | Details |
| 19278021 | Song C, Scharf ME: Mitochondrial impacts of insecticidal esters in insecticide-resistant and insecticide-susceptible Drosophila melanogaster. Pest Manag Sci. 2009 Jun;65(6):697-703. and three positive control treatments (rotenone, antimycin A and sodium cyanide) induced cytochrome c release, verifying that is capable of causing mitochondrial disruption. |
8(0,0,1,3) | Details |
| 19873237 | Krahl ME, Keltch AK, Neubeck CE, Clowes GH: STUDIES ON CELL METABOLISM AND CELL DIVISION : V. J Gen Physiol. 1941 May 20;24(5):597-617. The cytochrome oxidase was completely inhibited by sufficiently high concentrations of sodium cyanide, azide, and sulfide. An enzyme capable of oxidizing reduced cytochrome c (i.e. a cytochrome oxidase) has been obtained from Arbacia eggs. |
6(0,0,0,6) | Details |
| 12176748 | Li F, Mao HP, Ruchalski KL, Wang YH, Choy W, Schwartz JH, Borkan SC: Heat stress prevents mitochondrial injury in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol. 2002 Sep;283(3):C917-26. To test these hypotheses, renal epithelial cells were transiently ATP depleted with sodium cyanide and 2-deoxy- in the absence of medium Recovery from ATP depletion was associated with the release into the cytosol of cytochrome c and apoptosis-inducing factor (AIF), proapoptotic proteins that localize to the intermitochondrial membrane space. |
5(0,0,0,5) | Details |
| 10773165 | Moreno-Sanchez R, Covian R, Jasso-Chavez R, Rodriguez-Enriquez S, Pacheco-Moises F, Torres-Marquez ME: Oxidative phosphorylation supported by an alternative respiratory pathway in mitochondria from Euglena. Biochim Biophys Acta. 2000 Apr 21;1457(3):200-10. The effect of antimycin, myxothiazol, 2-heptyl-4-hydroxyquinoline-N-oxide, stigmatellin and on respiration, ATP synthesis, cytochrome c reductase, and membrane potential in mitochondria isolated from dark-grown Euglena cells was determined. |
4(0,0,0,4) | Details |
| 9399580 | Sakamoto J, Handa Y, Sone N: A novel cytochrome b (o/a) 3-type oxidase from Bacillus stearothermophilus catalyzes cytochrome c-551 oxidation. J Biochem. 1997 Oct;122(4):764-71. The oxidase activity was enhanced by the presence of salts and inhibited by sodium cyanide with a Ki value of 19 microM. |
4(0,0,0,4) | Details |
| 16749863 | Souid AK, Penefsky HS, Sadowitz PD, Toms B: Enhanced cellular respiration in cells exposed to doxorubicin. . Mol Pharm. 2006 May-Jun;3(3):307-21. Doxorubicin executes topoisomerase II mediated apoptosis, a process known to result in mitochondrial dysfunction, such as the leakage of cytochrome c and the opening of mitochondrial permeability transition pores (PTP). The conclusion that both of the latter processes were products of oxidations in the mitochondrial respiratory chain was supported by the further observation that rotenone and sodium cyanide inhibited consumption and substantially lowered ATP content in the treated and untreated cells. |
2(0,0,0,2) | Details |
| 2985190 | Acker H, Eyzaguirre C, Goldman WF: Redox changes in the mouse carotid body during hypoxia. . Brain Res. 1985 Mar 18;330(1):158-63. Wavelengths of 550 nm (maximal absorbance, MA) and 540 nm (isosbestic point, IP) were employed to study cytochrome c, 600 nm (MA) and 620 nm (IP) for a pigment presumed to be cytochrome aa3, 580 nm (MA) and 570 or 542 nm (IP) to control for possible effects of hemoglobin (Hb). |
2(0,0,0,2) | Details |
| 6313164 | Senciall IR, Bullock G, Rahal S: C21 hydroxylation and steroid carboxylic acid biosynthesis in the rabbit. Can J Biochem Cell Biol. 1983 Jul;61(7):722-30. Sodium cyanide had a stimulatory effect on the synthesis of pregnenoic acid by the liver but less consistent effects with other tissues. Cytochrome c (10 (-5) M), ferricyanide (10 (-3) M), and 2-methyl-1,2-di-3-pyridyl- 10 (-3) M) were strongly inhibitory with both tissues, whereas the liver microsomal system was less sensitive than the kidney to CO-air (90:10 v/v) inhibition. |
2(0,0,0,2) | Details |
| 2900731 | Shigenaga MK, Trevor AJ, Castagnoli N Jr: Metabolism-dependent covalent binding of (S)-[5-3H] to liver and lung microsomal macromolecules. Drug Metab Dispos. 1988 May-Jun;16(3):397-402. The addition of SKF 525-A, cytochrome c, or n-octylamine inhibited both (S)- metabolism and covalent binding whereas phenobarbital pretreatment increased the rates of metabolism and covalent binding. Sodium cyanide, which forms stable adducts with the cytochrome P-450-generated iminium ion metabolites of (S)- and a variety of other tertiary amines, inhibited covalent binding but also decreased the rate of (S)- metabolism. |
1(0,0,0,1) | Details |
| 16859701 | Hsieh YC, Yu HP, Suzuki T, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH: Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage. J Mol Cell Cardiol. 2006 Sep;41(3):511-21. Epub 2006 Jul 21. Depressed MRC activity has been reported to promote the release of cytochrome c from mitochondria and induce apoptosis. |
2(0,0,0,2) | Details |
| 12606726 | Niquet J, Baldwin RA, Allen SG, Fujikawa DG, Wasterlain CG: Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2825-30. Epub 2003 Feb 26. Early mitochondrial swelling and loss of the mitochondrial membrane potential were accompanied by release of cytochrome c and followed by caspase-9-dependent activation of caspase-3. |
2(0,0,0,2) | Details |
| 684869 | Popov IP: zinc and content and activity of respiratory metalloenzymes in animal tissues under toxic hypoxia]. Ukr Biokhim Zh. 1978 Jul-Aug;50(4):424-8. The rabbits being repeatedly poisoned with small doses of sodium cyanide, the activity of succinic dehydrogenase in the tissues does not essentially change. The activity of NAD.H2-cytochrome-c-reductase and NAD.H2-diaphorase in the brain, myocardium and kidneys increases. |
2(0,0,0,2) | Details |
| 6662501 | Ogawa H, Nagamura Y, Ishiguro I: Xanthommatin formation in rat liver mitochondria and its inhibition by respiratory chain substrates. Hoppe Seylers Z Physiol Chem. 1983 Nov;364(11):1519-25. is condensed to xanthommatin by cytochrome c and cytochrome oxidase in rat liver mitochondria. |
1(0,0,0,1) | Details |
| 9509413 | An SS, Kim YM: Purification and characterization of a manganese-containing superoxide dismutase from a carboxydobacterium, Pseudomonas carboxydohydrogena. Mol Cells. 1997 Dec 31;7(6):730-7. azide, but not sodium cyanide and peroxide, was found to inhibit the enzyme activity. The final specific activity was 2,396 units per mg protein as determined by an assay based on a 50% decrease in the rate of cytochrome c reduction. |
1(0,0,0,1) | Details |
| 16697116 | Niquet J, Seo DW, Allen SG, Wasterlain CG: Hypoxia in presence of blockers of excitotoxicity induces a caspase-dependent neuronal necrosis. Neuroscience. 2006 Aug 11;141(1):77-86. Epub 2006 May 11. They showed early mitochondrial swelling, loss of mitochondrial membrane potential and cytoplasmic release of cytochrome c, followed by activation of caspase-9, and by caspase-9-dependent activation of caspase-3. |
1(0,0,0,1) | Details |
| 17646712 | Seo SN, Lee JH, Kim YM: Characterization of an iron- and manganese-containing superoxide dismutase from Methylobacillus sp. strain SK1 DSM 8269. Mol Cells. 2007 Jun 30;23(3):370-8. peroxide and azide, but not sodium cyanide, was found to inhibit the purified enzyme. The final specific activity was 4,831 units per milligram protein as determined by an assay based on a 50% decrease in the rate of cytochrome c reduction. |
1(0,0,0,1) | Details |
| 11385136 | Sakamoto T, Jonas RA, Stock UA, Hatsuoka S, Cope M, Springett RJ, Nollert G: Utility and limitations of near-infrared spectroscopy during cardiopulmonary bypass in a piglet model. Pediatr Res. 2001 Jun;49(6):770-6. Study animals (n = 10) received 100 mg/kg of sodium cyanide to uncouple cytochrome from HB: Hematocrit was then decreased in steps of 5% from 35 to 5% with crystalloid hemodilution. caused oxygenated Hb to increase further to 132.3 +/- 48.9 microM times the differential path-length factor, and oxidized cytochrome c decreased to -7.0 +/- 2.6 microM times the differential path-length factor as anticipated, confirming uncoupling of electron transport. |
1(0,0,0,1) | Details |
| 9309676 | Loffler M, Jockel J, Schuster G, Becker C: Dihydroorotat- oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Mol Cell Biochem. 1997 Sep;174(1-2):125-9. The application of known enzyme inhibitors Brequinar and Leflunomide for DHODH and sodium cyanide for cytochrome c oxidase verified the specificity of the activity tests used. For comparison, the cytochrome c and -dependent consumption of mitochondria from different tissues was measured. |
1(0,0,0,1) | Details |
| 11004582 | Pereira IA, LeGall J, Xavier AV, Teixeira M: Characterization of a heme c reductase from a non-ammonifying microorganism, Desulfovibrio vulgaris Hildenborough. Biochim Biophys Acta. 2000 Aug 31;1481(1):119-30. It was isolated from the membranes as a large heterooligomeric complex of 760 kDa, containing two cytochrome c subunits of 56 and 18 kDa. |
1(0,0,0,1) | Details |
| 12930708 | Ruchalski K, Mao H, Singh SK, Wang Y, Mosser DD, Li F, Schwartz JH, Borkan SC: HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol. 2003 Dec;285(6):C1483-93. Epub 2003 Aug 20. To evaluate this hypothesis, cells were transiently exposed to 5 mM sodium cyanide in the absence of medium a maneuver known to induce apoptosis. |
0(0,0,0,0) | Details |
| 1308986 | Balla J, Jacob HS, Balla G, Nath K, Vercellotti GM: Endothelial cell heme oxygenase and ferritin induction by heme proteins: a possible mechanism limiting shock damage. Trans Assoc Am Physicians. 1992;105:1-6. needs to be released from methemoglobin, since sodium cyanide, haptoglobin, and hemopexin inhibit the induction of these proteins. |
0(0,0,0,0) | Details |