Protein Information

Name Substance P
Synonyms Hs.2563; PPT; NK2; NKA; NKNA; Neurokinin 1; Neurokinin 2; Neurokinin A…

Compound Information

Name sodium cyanide
CAS sodium cyanide (Na(CN))

Reference List

PubMed Abstract RScore(About this table)
1706884 Haxhiu MA, Haxhiu-Poskurica B, Moracic V, Carlo WA, Martin RJ: Reflex and chemical responses of tracheal submucosal glands in piglets. Respir Physiol. 1990 Dec;82(3):267-77.

In adult animals, airway fluid secretion is enhanced reflexly via central nervous system pathways, and locally by mediators such as substance P.
Furthermore, administration of sodium cyanide had little or no effect on baseline secretion.
4(0,0,0,4) Details
6157809 McQueen DS: Effects of substance P on carotid chemoreceptor activity in the cat. J Physiol. 1980 May;302:31-47.

2(0,0,0,2) Details
2411343 Monti-Bloch L, Eyzaguirre C: Effects of methionine-enkephalin and substance P on the chemosensory discharge of the cat carotid body. Brain Res. 1985 Jul 15;338(2):297-307.

2(0,0,0,2) Details
6166957 McQueen DS, Ribeiro JA: Effects of beta-endorphin, vasoactive intestinal polypeptide and cholecystokinin octapeptide on cat carotid chemoreceptor activity. Q J Exp Physiol. 1981 Jul;66(3):273-84.

The chemoexcitation evoked by acetylcholine and sodium cyanide was reduced during intracarotid infusion of any of the three peptides studied, and that caused by CO2-saturated Locke solution was reduced by beta-endorphin, largely unaltered by VIP and variably affected by CCK-8.
Substance P was unable to overcome the chemoinhibitory effect of methionine enkephalin.
1(0,0,0,1) Details
10562346 Paton JF, Kasparov S: Differential effects of angiotensin II on cardiorespiratory reflexes mediated by nucleus tractus solitarii - a microinjection study in the rat. J Physiol. 1999 Nov 15;521 Pt 1:213-25.

The ANGII effect on the cardiac component of the chemoreceptor reflex is bi-directional being inhibited at low concentrations and potentiated at higher concentrations; the latter involves NK1 receptors and presumably results from release of substance P.
Baroreceptors were stimulated by raising perfusion pressure and chemoreceptors were activated with aortic injections of sodium cyanide (0.025 %, 25-75 microl).
1(0,0,0,1) Details
3921196 Zapata P, Eyzaguirre C: Bioelectric potentials in the carotid body. . Brain Res. 1985 Apr 1;331(1):39-50.


However, cholinergic agents, dopamine and substance P evoked sVs which lacked correlation in time-course, amplitude or polarity with changes in sensory frequency.
1(0,0,0,1) Details