Protein Information

Name glutamic acid decarboxylase
Synonyms 65 kDa glutamic acid decarboxylase; GAD 2; GAD 65; GAD2; GAD65; Glutamate decarboxylase 2; Glutamate decarboxylase 2 (pancreas); Glutamate decarboxylase 65 kDa isoform…

Compound Information

Name sodium cyanide
CAS sodium cyanide (Na(CN))

Reference List

PubMed Abstract RScore(About this table)
16455687 Takakura AC, Moreira TS, Colombari E, West GH, Stornetta RL, Guyenet PG: Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats. J Physiol. 2006 Apr 15;572(Pt 2):503-23. Epub 2006 Feb 2.

In urethane-chloralose-anaesthetized rats, bilateral inhibition of the RTN with muscimol eliminated the phrenic nerve discharge (PND) at rest, during hyperoxic hypercapnia (10% CO (2)), and during peripheral chemoreceptor stimulation (hypoxia and/or i.v. sodium cyanide, NaCN).
Within RTN, 51% of BDA-labelled axonal varicosities contained detectable levels of vesicular glutamate transporter-2 (VGLUT2) but only 5% contained glutamic acid decarboxylase-67 (GAD67).
1(0,0,0,1) Details
1956876 Cassel G, Karlsson L, Sellstrom A: On the inhibition of glutamic acid decarboxylase and gamma-aminobutyric acid transaminase by sodium cyanide. Pharmacol Toxicol. 1991 Oct;69(4):238-41.

The effects of sodium cyanide (NaCN) on the gamma-aminobutyric acid metabolizing enzymes glutamic acid decarboxylase (GAD) and gamma-aminobutyric acid transaminase (GABA-T) were studied in vitro.
112(1,2,2,2) Details