Protein Information

Name sodium channel (protein family or complex)
Synonyms Sodium channel

Compound Information

Name sodium cyanide
CAS sodium cyanide (Na(CN))

Reference List

PubMed Abstract RScore(About this table)
11080255 Hammarstrom AK, Gage PW: Oxygen-sensing persistent sodium channels in rat hippocampus. . J Physiol. 2000 Nov 15;529 Pt 1:107-18.

Sodium cyanide (NaCN, 5 mM; 0.5-5 min) increased persistent sodium channel activity in cell-attached patches (n = 3) in a similar manner. 3.
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20019330 Tan ZY, Lu Y, Whiteis CA, Simms AE, Paton JF, Chapleau MW, Abboud FM: Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR. Circ Res. 2010 Feb 19;106(3):536-45. Epub 2009 Dec 17.

One is the amiloride-sensitive acid-sensing sodium channel (ASIC3), which is activated by low pH and the other is the 2-pore domain acid-sensing K (+) channel (TASK1), which is inhibited by low pH and blocked by quinidine.
Moreover, we found that the increase in sympathetic nerve activity in response to stimulation of chemoreceptors with sodium cyanide was markedly enhanced in the still normotensive young SHR compared to control WKY rats.
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8381823 Cummins TR, Jiang C, Haddad GG: Human neocortical excitability is decreased during anoxia via sodium channel modulation. J Clin Invest. 1993 Feb;91(2):608-15.

1(0,0,0,1) Details