| Name | methemoglobin |
|---|---|
| Synonyms | Abnormal hemoglobin; G gamma globin; Gamma 2 globin; HBG 2; HBG2; Hb F Ggamma; Hemoglobin gamma G; Hemoglobin gamma 2 chain… |
| Name | sodium cyanide |
|---|---|
| CAS | sodium cyanide (Na(CN)) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1335620 | Tadic V: The in vivo effects of and its antidotes on rat brain cytochrome oxidase activity. Toxicology. 1992 Nov 22;76(1):59-67. The in vivo effects of sodium cyanide and its antidotes, and 4-dimethylaminophenol as well as the alpha-adrenergic blocking agent phentolamine, on rat brain cytochrome oxidase were studied. |
0(0,0,0,0) | Details |
| 1308986 | Balla J, Jacob HS, Balla G, Nath K, Vercellotti GM: Endothelial cell heme oxygenase and ferritin induction by heme proteins: a possible mechanism limiting shock damage. Trans Assoc Am Physicians. 1992;105:1-6. needs to be released from methemoglobin, since sodium cyanide, haptoglobin, and hemopexin inhibit the induction of these proteins. |
35(0,1,1,5) | Details |
| 2844117 | Moreno SN, Stolze K, Janzen EG, Mason RP: Oxidation of to the cyanyl radical by peroxidase/H2O2 systems as determined by spin trapping. Arch Biochem Biophys. 1988 Sep;265(2):267-71. The cyanyl radical was formed during the oxidation of or sodium cyanide by horseradish peroxidase, lactoperoxidase, chloroperoxidase, peroxidase, or methemoglobin in the presence of peroxide. |
31(0,1,1,1) | Details |
| 2860882 | Vick JA, Froehlich HL: Studies of poisoning. Arch Int Pharmacodyn Ther. 1985 Feb;273(2):314-22. Sixty anesthetized beagle dogs were injected i.v. with sodium cyanide (2.5 mg/kg) and were followed for changes in the heart rate, electrocardiogram, respiration, blood pressure and methemoglobin concentration. |
7(0,0,1,2) | Details |
| 839120 | Levine S: Interaction between ethyl methylene blue and -induced increases in blood lactate. J Lab Clin Med. 1977 Mar;89(3):632-9. Accordingly, sodium cyanide (1.2 mg./Kg.) was infused into the abdominal aorta of anesthetized, spontaneously breathing dogs. A second group of dogs was pretreated with EMB (8 to 15 mg./Kg.); this dose of EMB elicited twofold increments in consumption and induced the formation in vivo of methemoglobin (0.8 +/- 0.1 gm./100 ml.). |
3(0,0,0,3) | Details |
| 1592224 | Scharf BA, Fricke RF, Baskin SI: Comparison of methemoglobin formers in protection against the toxic effects of Gen Pharmacol. 1992 Jan;23(1):19-25. The compounds were administered 15 or 60 min before an intramuscular (i.m.) challenge with a 2 x LD50 dose (5.0-5.6 mg/kg) of sodium cyanide (NaCN). 5. |
2(0,0,0,2) | Details |
| 6676476 | Ten Eyck RP, Schaerdel AD, Lynett JE, Marks DH, Patrissi GA, Ottinger WE, Stansell MJ: Stroma-free methemoglobin solution as an antidote for poisoning: a preliminary study. J Toxicol Clin Toxicol. 1983-1984;21(3):343-58. |
2(0,0,0,2) | Details |
| 8845203 | Baskin SI, Nealley EW, Lempka JC: toxicity in mice pretreated with diethylamine complex. Hum Exp Toxicol. 1996 Jan;15(1):13-18. a vasodilator commonly used to treat toxicity thought to act by methemoglobin (MHb) formation, can be rapidly transformed to (NO). 2. Mice (n = 10 per dose) were administered one of five doses of sodium cyanide (NaCN) intraperitoneally (4.28, 5.08, 6.03, 7.17 and 8.52 mg kg-1). |
1(0,0,0,1) | Details |
| 10362268 | Baskin SI, Porter DW, Rockwood GA, Romano JA Jr, Patel HC, Kiser RC, Cook CM, Ternay AL Jr: In vitro and in vivo comparison of donors as antidotes to acute intoxication. J Appl Toxicol. 1999 May-Jun;19(3):173-83. Although studies to elucidate the precise mechanisms are needed. it is clear that these newly synthesized compounds provide a new rationale for anti-CN drugs, with fewer side-effects than the methemoglobin formers. The ability of SSDs to protect mice against 2LD50 of sodium cyanide (NaCN) administered either 15 or 60 min following administration of an SSD was assessed. |
1(0,0,0,1) | Details |