| Name | pyruvate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | Pyruvate dehydrogenase; Pyruvate dehydrogenases |
| Name | sodium cyanide |
|---|---|
| CAS | sodium cyanide (Na(CN)) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 4084575 | Stepp LR, Reed LJ: Active-site modification of mammalian pyruvate dehydrogenase by Biochemistry. 1985 Dec 3;24(25):7187-91. The pyruvate dehydrogenase multienzyme complex from bovine kidney and heart is inactivated by treatment with and sodium cyanide or borohydride. |
33(0,1,1,3) | Details |
| 7938918 | Uchida K, Doi K: Glycolysis vs. respiration as ATP source for the shape of quiescent cardiomyocytes. Respir Physiol. 1994 Jul;97(2):213-23. Inhibition of the oxidative phosphorylation by sodium cyanide (CN, 2 mM) or 2,4-dinitrophenol (DNP, 40 microM) did not induce significant [ATP] reduction (56.5 +/- 5.6 or 53.2 +/- 7.5). Under glycolytic inhibition with DG, addition of (5 mM) with a pyruvate dehydrogenase activator (dichloroacetate (DCA, 1 mM) or (-) isoproterenol (ISO, 10 microM)) restored [ATP] to 52.5 +/- 8.3 and 67.7 +/- 7.2, respectively, but Rrod still remained depressed (34.6 +/- 2.1 and 35.4 +/- 1.3%). |
1(0,0,0,1) | Details |
| 870085 | Lefresne P, Hamon M, Beaujouan JC, Glowinski J: Origin of the acetyl moiety of synthesized in rat striatal synaptosomes. Biochimie. 1977;59(2):197-215. The experimental value obtained from a 10 min incubation, after the nerve endings had reached a steady metabolic activity, indicate that if the acetyl moiety of was derived from some Krebs cycle intermediary compounds, its SRA could never exceed 55 per cent that of the [2-14C] from which it is produced, (iv) No correlation could be found between the rate of [14C] formation and changes in the Krebs cycle activity induced by sodium cyanide, 2-4 dinitrophenol and Ca2+ free medium. (v) The lack of significant [14C] synthesis from [1-14C] in striatal synaptosomes is consistent with the failure of fluoroacetate to modify the amounts of 14CO2 as well as of [14C] formed from [2-14C] To reconcile all these data, it is proposed that is transformed into AcCoA outside the mitochondria by the action of some cytoplasmic pyruvate dehydrogenase-like enzyme. |
1(0,0,0,1) | Details |