| 18783804 |
Maiale SJ, Marina M, Sanchez DH, Pieckenstain FL, Ruiz OA: In vitro and in vivo inhibition of plant polyamine oxidase activity by polyamine analogues. Phytochemistry. 2008 Oct;69(14):2552-8. Epub 2008 Sep 8.
In addition, in vitro enzymatic activity assays showed that the oligoamine [3,8,13,18,23,28,33,38,43,48-deca-aza-(trans-25)-pentacontene], the tetramine 1,14-bis-[ethylamino]-5,10-diazatetradecane, and the pentamine 1,19-bis-[ethylamino]-5,10,15-triazanonadecane, displayed potent competitive inhibitory activities against polyamine oxidase with K (i) values of 5.8, 110.0 and 7.6 nM, respectively, where cyclohexylamine was a weak competitive inhibitor with a K (i) value of 0.5 mM. |
87(1,1,1,7) |
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