| Name | lactate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | LDH; lactate dehydrogenase; lactate dehydrogenases |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18243470 | Rankin GO, Hong SK, Anestis DK, Ball JG, Valentovic MA: Mechanistic aspects of 4-amino-2,6-dichlorophenol-induced in vitro nephrotoxicity. Toxicology. 2008 Mar 12;245(1-2):123-9. Epub 2007 Dec 27. In vitro, ADCP exposure increases lactate dehydrogenase (LDH) release from rat renal cortical slices at 0.05 mM or greater. Inhibitors of CYP piperonyl butoxide and isoniazid) and FMO activity modulators (methimazole, N-octylamine) had no effect on ADCP cytotoxicity. |
1(0,0,0,1) | Details |
| 2718172 | Clay RJ, Morris JB: Comparative pneumotoxicity of cyclopentadienyl tricarbonyl and methylcyclopentadienyl tricarbonyl. Toxicol Appl Pharmacol. 1989 May;98(3):434-43. Piperonyl butoxide diminished both the pneumotoxicity and Mn accumulation resulting from CMT or MMT, suggesting both phenomena are due to monooxygenase metabolites. The pneumotoxic response to either compound was characterized by large increases in lavage albumin and protein content with smaller increases in lactate dehydrogenase levels. |
1(0,0,0,1) | Details |
| 9215992 | Sriram K, Boyd MR, Vistica DT, Ravindranath R: In vitro neurotoxicity of the antitumor agent 9-methoxy-N2-methylellipticinium (MMEA): role of brain cytochrome P-450. Neurotoxicology. 1997;18(1):97-104. Incubation of rat brain slices in an artificial cerebrospinal fluid medium containing MMEA resulted in dose-dependent leakage of lactate dehydrogenase (LDH) into the surrounding medium. Pretreatment of slices with piperonyl butoxide and inhibitor of cytochrome P-450, also prevented the toxicity of MMEA. |
1(0,0,0,1) | Details |
| 7861152 | Sriram K, Pai KS, Ravindranath V: Protection and potentiation of 1-methyl-4-phenylpyridinium-induced toxicity by cytochrome P450 inhibitors and inducer may be due to the altered uptake of the toxin. J Neurochem. 1995 Mar;64(3):1203-8. MPP (+)-induced toxicity was abolished by pretreatment of the slices with inhibitors of monoamine oxidase (MAO; pargyline and deprenyl) or inhibitors of P450 (piperonyl butoxide or SKF-525A) or uptake blocker (GBR-12909), as measured by the activity of -DH in slices and leakage of lactate dehydrogenase from the slice into the medium. |
32(0,1,1,2) | Details |
| 6872100 | Imamura T, Hasegawa L, Gandy J, Fukuto TR: Effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate-induced delayed toxicity in rats. Chem Biol Interact. 1983 Jul 1;45(1):53-64. Pretreatment with phenobarbital, piperonyl butoxide (2 h), SKF 525-A, or small multiple doses of OOS protected against the OOS-induced elevated level of bronchopulmonary lavage LDH, and the other signs of delayed toxicity including morphological alteration of Clara cells. |
7(0,0,1,2) | Details |
| 1933335 | Pai KS, Ravindranath V: Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices. Brain Res. 1991 Aug 2;555(2):239-44. Leakage of lactate dehydrogenase from the slice into the medium was observed following incubation of slices with 1 nM MPTP. Other cytochrome P-450 inhibitors, namely, piperonyl butoxide and SKF 525A were found to offer protection against MPTP induced neurotoxicity in slices without affecting monoamine oxidase activity. |
1(0,0,0,1) | Details |
| 8014883 | Fau D, Eugene D, Berson A, Letteron P, Fromenty B, Fisch C, Pessayre D: Toxicity of the antiandrogen flutamide in isolated rat hepatocytes. . J Pharmacol Exp Ther. 1994 Jun;269(3):954-62. This was associated with an early increase in phosphorylase a activity (a Ca (++)-dependent enzyme) and a decrease in cytoskeleton-associated protein thiols, the formation of plasma membrane blebs, the release of lactate dehydrogenase (LDH) and a loss of cell viability. Both covalent binding and LDH release were decreased by piperonyl butoxide (an inhibitor of cytochrome P450) and increased by dexamethasone pretreatment (which induces cytochrome P450 3A). |
1(0,0,0,1) | Details |
| 18214888 | Rankin GO, Racine C, Sweeney A, Kraynie A, Anestis DK, Barnett JB: In vitro nephrotoxicity induced by propanil. Environ Toxicol. 2008 Aug;23(4):435-42. In IRCC pretreated with an antioxidant, cytochrome P450 (CYP) inhibitor, monooxygenase activity modulator, or cyclooxygenase inhibitor before propanil exposure (1.0 mM; 120 min), only piperonyl butoxide (0.1 mM), a CYP inhibitor, pretreatment decreased propanil cytotoxicity. Cytotoxicity was determined by measuring lactate dehydrogenase release from IRCC. |
1(0,0,0,1) | Details |