| Name | alcohol dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | ADH; alcohol dehydrogenase; alcohol dehydrogenases |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9414486 | Feldwick MG, Noakes PS, Prause U, Mead RJ, Kostyniak PJ: The biochemical toxicology of 1,3-difluoro- the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote. J Biochem Mol Toxicol. 1998;12(1):41-52. The conversion of 1,3-difluoro- to 1,3-difluoroacetone was found to be catalyzed by an (+)-dependent alcohol dehydrogenase, while the defluorination was attributed to microsomal monooxygenase activity induced by phenobarbitone and inhibited by piperonyl butoxide. 4-Methylpyrazole was found to inhibit both of these processes in vitro and when administered (90 mg kg-1 body weight) to rats, 2 hours prior to 1,3-difluoro- eliminated signs of poisoning, prevented (-) erythrofluorocitrate synthesis, and markedly decreased and accumulation in vivo. 4-Methylpyrazole also appeared to diminish (-) erythrofluorocitrate synthesis from fluoroacetate in vivo, and this was attributed to its capacity to inhibit malate dehydrogenase activity. |
31(0,1,1,1) | Details |
| 19883652 | Guo L, Zeng XY, Wang DY, Li GQ: metabolism in the Asian corn borer, Ostrinia furnacalis (Guenee) (Lepidoptera: Pyralidae). J Insect Physiol. 2010 Mar;56(3):260-5. Epub 2009 Nov 11. Toxicity of was enhanced by 4-methylpyrazole, 3-amino-1,2,4-triazole and piperonyl butoxide, and toxicity of was increased by 3-amino-1,2,4-triazole and piperonyl butoxide. These data indicate that alcohol dehydrogenase, and probably catalase and cytochrome P450 monooxygenase oxidize to catalase and cytochrome P450 monooxygenase catalyze to water and and carboxylesterase may have a minor effect. |
1(0,0,0,1) | Details |