| Name | uroporphyrinogen decarboxylase |
|---|---|
| Synonyms | PCT; UPD; URO D; UROD; Uroporphyrinogen III decarboxylase; Uroporphyrinogen decarboxylase; Uroporphyrinogen III decarboxylases; Uroporphyrinogen decarboxylases |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6435605 | Sinclair PR, Bement WJ, Bonkovsky HL, Sinclair JF: Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Biochem J. 1984 Sep 15;222(3):737-48. Use of inhibitors of the P-450 and P-448 isoenzymes (SKF-525A, piperonyl butoxide and ellipticine) supported the concept that only the P-448 isoenzyme is involved in the inhibition of the decarboxylase by the halogenated biphenyls. |
2(0,0,0,2) | Details |
| 3800966 | Smith AG, Francis JE, Kay SJ, Greig JB, Stewart FP: Mechanistic studies of the inhibition of hepatic uroporphyrinogen decarboxylase in C57BL/10 mice by iron-hexachlorobenzene synergism. Biochem J. 1986 Sep 15;238(3):871-8. Although, in further studies, total microsomal cytochrome P-450 content and ethoxyphenoxazone de-ethylase activity reached a peak a few days after dosing and had declined significantly at the time of maximum inhibition of the decarboxylase, additional treatment of HCB-dosed mice with a cytochrome P1-450 inducer, beta-naphthoflavone, enhanced the inhibition, whereas piperonyl butoxide, an inhibitor of cytochrome P-450, partially protected. |
2(0,0,0,2) | Details |
| 3026315 | Sinclair PR, Bement WJ, Bonkovsky HL, Lambrecht RW, Frezza JE, Sinclair JF, Urquhart AJ, Elder GH: Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Biochem J. 1986 Jul 1;237(1):63-71. We conclude that the mechanism of the uroporphyrin accumulation cannot be due to covalent binding of activated metabolites of halogenated compounds to uroporphyrinogen decarboxylase. Reversal of the accumulation by piperonyl butoxide.. |
1(0,0,0,1) | Details |
| 2759551 | Bonkovsky HL: Mechanism of iron potentiation of hepatic uroporphyria: studies in cultured chick embryo liver cells. Hepatology. 1989 Sep;10(3):354-64. Uroporphyrinogen decarboxylase activity was unchanged by drug and iron treatments. Inhibitors of P-450-phenobarbital, SKF525A and piperonyl butoxide, as well as cadmium and cycloheximide prevented the accumulation produced by glutethimide + iron, even though, except with cycloheximide, these substances further increased synthase activity. |
1(0,0,0,1) | Details |
| 7233443 | Debets FM, Reinders JH, Debets AJ, Lossbroek TG, Strik JJ, Koss G: Biotransformation and porphyringogenic action of hexachlorobenzene and its metabolites in a primary liver cell culture. Toxicology. 1981;19(3):185-96. Addition of the monooxygenase-inhibitor piperonyl butoxide or decreased the irreversible binding of 14C-metabolites. Since none of the main HCB-metabolites could induce a pathological pattern, a reactive intermediate capable of reacting with or thiol-groups of uroporphyrinogen decarboxylase (UROG-D) is believed to be responsible for the inhibition of UROG-D. |
1(0,0,0,1) | Details |
| 3718476 | Sinclair JF, Zaitlin LM, Smith EL, Howell SK, Bonkovsky HL, Sinclair PR: Induction of synthase by two- to five-carbon in cultured chick-embryo hepatocytes. Biochem J. 1986 Mar 1;234(2):405-11. In the presence of 3,4,3',4'-tetrachlorobiphenyl, an inhibitor of haem synthesis at the uroporphyrinogen decarboxylase step, synergistic induction of synthase was observed with all the except |
1(0,0,0,1) | Details |