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Frater Y, Brady A, Lock EA, De Matteis F: Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Arch Toxicol. 1993;67(3):179-85.
Mice given a single dose of the drug showed 24 h later a 70% inhibition of liver ferrochelatase and marked accumulation of protoporphyrin.
Two inhibitors of liver cytochrome P450, compound SKF 525-A and piperonyl butoxide, when given before ATMP, afforded protection against ATMP-induced porphyria and production of N-methyl protoporphyrin, suggesting a role of cytochrome P450 in the induction of the metabolic disorder. |
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