| Name | cytochrome P450 reductase |
|---|---|
| Synonyms | CPR; CYPOR; Cytochrome P 450 reductase; Cytochrome P450 reductase; NADPH cytochrome P450 reductase; NADPH cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450R… |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18615616 | Boonsuepsakul S, Luepromchai E, Rongnoparut P: Characterization of Anopheles minimus CYP6AA3 expressed in a recombinant baculovirus system. Arch Insect Biochem Physiol. 2008 Sep;69(1):13-21. The enzymatic activity of CYP6AA3 in deltamethrin metabolism was characterized after being reconstituted with An. minimus NADPH-cytochrome P450 reductase and a -regenerating system. Deltamethrin degradation and formation of metabolites were -dependent and inhibited by piperonyl butoxide. |
1(0,0,0,1) | Details |
| 8386241 | Berson A, Wolf C, Chachaty C, Fisch C, Fau D, Eugene D, Loeper J, Gauthier JC, Beaune P, Pompon D, et al.: Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies. J Pharmacol Exp Ther. 1993 Apr;265(1):366-72. Covalent binding required and and was decreased by the nucleophile and by the cytochrome P-450 inhibitors SKF 525-A, piperonyl butoxide and troleandomycin (an inhibitor of the cytochrome P-450 3A subfamily). |
0(0,0,0,0) | Details |
| 10333321 | Kotze AC: Peroxide-supported in-vitro cytochrome P450 activities in Haemonchus contortus. Int J Parasitol. 1999 Mar;29(3):389-96. Larval activity was inhibited by typical cytochrome P450 inhibitors (piperonyl butoxide, SKF-525A, chloramphenicol, n-octylamine) and was unaffected by the peroxidase inhibitor salicylhydroxamic acid. |
0(0,0,0,0) | Details |
| 2841540 | Chakraborty C, Davis DL, Dey SK: Characteristics of -2/4-hydroxylase in pig blastocysts: inhibition by steroidal and nonsteroidal agents. J Steroid Biochem. 1988 Aug;31(2):231-5. Although alpha-naphthoflavone and aminoglutethimide did not affect E-2/4-H activity in vitro, inhibition by CO (95% CO + 5% O2), SKF-525A, piperonyl butoxide, and antibody to cytochrome P-450 reductase provides evidence for the involvement of cytochrome P-450 in E-2/4-H activity in pig blastocysts. |
0(0,0,0,0) | Details |
| 2155354 | Chakraborty C, Davis DL, Dey SK: -15 alpha-hydroxylation: a new avenue of metabolism in peri-implantation pig blastocysts. J Steroid Biochem. 1990 Feb;35(2):209-18. The enzyme activity was inhibited by different steroidal compounds and non-steroidal estrogens, as well as by CO, SKF-525A, piperonyl butoxide and antibody to cytochrome P450 reductase. |
31(0,1,1,1) | Details |
| 2691105 | Madyastha KM, Moorthy B: Pulegone mediated hepatotoxicity: evidence for covalent binding of R (+)-[14C] pulegone to microsomal proteins in vitro. Chem Biol Interact. 1989;72(3):325-33. Covalent binding was drastically inhibited (93%) in the presence of piperonyl butoxide. Antibodies to phenobarbital-induced cytochrome P-450 and -cytochrome P-450 reductase inhibited covalent binding to an extent of 72% and 47%, respectively. |
1(0,0,0,1) | Details |
| 3983973 | Levi PE, Hodgson E: Oxidation of pesticides by purified cytochrome P-450 isozymes from mouse liver. Toxicol Lett. 1985 Feb-Mar;24(2-3):221-8. 5 cytochrome P-450 isozymes were purified from the livers of uninduced mice and reconstituted with purified cytochrome P-450 reductase and phospholipid. All fraction metabolized the pesticide synergist piperonyl butoxide (PBO) to form an inhibitory cytochrome P-450-PBO-metabolite complex. |
1(0,0,0,1) | Details |