Protein Information

Name enolase
Synonyms 2 phospho D glycerate hydrolyase; T suppressor LYMPHOKINE; 2 phospho D glycerate hydro lyase; Enolase; Beta enolase; ENO 3; ENO3; Enolase 3…

Compound Information

Name piperonyl butoxide
CAS 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
2936317 Sakamoto J, Hashimoto K: Effect of acrylamide and related compounds on glycolytic enzymes in mouse brain in vitro. Arch Toxicol. 1985 Sep;57(4):276-81.

A neurotoxic compound, N-isopropylacrylamide, and a non-neurotoxic compound, N,N'-methylene-bis-acrylamide, showed non-competitive inhibition towards mouse brain total enolase.
After preincubation with S-9 fraction prepared from either diethyl maleate-, or piperonyl butoxide-pretreated mice the inhibitory potency was significantly greater than with non-pretreated control mice.
2(0,0,0,2) Details
9215992 Sriram K, Boyd MR, Vistica DT, Ravindranath R: In vitro neurotoxicity of the antitumor agent 9-methoxy-N2-methylellipticinium acetate (MMEA): role of brain cytochrome P-450. Neurotoxicology. 1997;18(1):97-104.

However, other subcellular marker enzymes such as Na (+)-K+ATPase (plasma membrane), cytochrome c oxidase, isocitrate dehydrogenase, NADH-dehydrogenase (mitochondrial), N-acetylglucosaminidase, acid phosphate (lysosomal), glyceraldehyde-3-phosphate dehydrogenase and enolase (glycolytic enzymes) were unaffected even at the highest tested concentrations of MMEA (10 and 100 microM).
Pretreatment of slices with piperonyl butoxide and metyrapone, inhibitor of cytochrome P-450, also prevented the toxicity of MMEA.
1(0,0,0,1) Details