| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16162970 | Brandon EF, Meijerman I, Klijn JS, den Arend D, Sparidans RW, Lazaro LL, Beijnen JH, Schellens JH: In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction. Anticancer Drugs. 2005 Oct;16(9):935-43. In-vitro studies have shown that ET-743 is mainly metabolized by cytochrome P450 (CYP) 3A4, but also by 2C9, 2C19, 2D6 and 2E1, and the phase II enzymes diphosphoglucuronosyl transferase and glutathione-S-transferase. Potent cytotoxic activity of ET-743 after 120 h treatment was observed, which could be increased in combination with the CYP inhibitors (3A4), phenanthrene (substrate for 2E1, 3A4), piperonyl butoxide (3A), proadifen (2C9, 2E1, 3A4), ritonavir (3A4), and (2C9, 2C19). |
1(0,0,0,1) | Details |
| 6547180 | Fouin-Fortunet H, Letteron P, Tinel M, Degott C, Flejou JF, Pessayre D: Mechanism for isaxonine hepatitis. J Pharmacol Exp Ther. 1984 Jun;229(3):851-8. Coincubation of 0.4 mM [3H] with 4 mM isaxonine , an -generating system, glutathione S-transferase and mouse liver microsomes, followed by thin-layer chromatography of the incubation mixture, resulted in the appearance of a 3H-labeled peak with characteristics consistent with a - isaxonine metabolite adduct: this peak was absent if either isaxonine or the -generating system was omitted and was decreased if the transferase was omitted. In vivo, the concentrations of hepatic and were markedly decreased 2.5 hr after administration of isaxonine (4 mmol X kg-1 i.p.); this depletion of was prevented essentially by pretreatment with piperonyl butoxide. |
1(0,0,0,1) | Details |
| 2069422 | Podowski AA, Sclove SL, Pilipowicz A, Khan MA: Biotransformation and disposition of hexachlorocyclopentadiene in fish. Arch Environ Contam Toxicol. 1991 May;20(4):488-96. The inhibitors of the microsomal P-450 oxygenases (piperonyl butoxide) and UDPGA-transferase (salicylamide) do not affect the toxicity of HEX to goldfish fingerlings, indicating that its toxicity may not be related to these pathways. |
0(0,0,0,0) | Details |