Protein Information

Name glucose 6 phosphatase
Synonyms G 6 Pase; G6PC; G6PT; G6Pase; GSD1a; Glucose 6 phosphatase; Glucose 6 phosphatase hydrolytic subunit; G6Pases…

Compound Information

Name piperonyl butoxide
CAS 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
13973 Melancon MJ, Lech JJ: Metabolism of di-2-ethylhexyl phthalate by subcellular fractions from rainbow trout liver. Drug Metab Dispos. 1977 Jan-Feb;5(1):29-36.

Both hydrolysis and oxidative metabolism of DEHP were inhibited by piperonyl butoxide.
Measurement of the microsomal marker, glucose 6-phosphatase, and the mitochondrial marker, succinic dehydrogenase, revealed that DEHP-hydrolytic activity was associated with microsomes and the 100,000g supernatant fraction, whereas DEHP oxidation was associated only with microsomes.
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2541521 Moorthy B, Madyastha P, Madyastha KM: Hepatotoxicity of pulegone in rats: its effects on microsomal enzymes, in vivo. Toxicology. 1989 May 15;55(3):327-37.

Massive hepatotoxicity accompanied by an increase in serum glutamate pyruvate transaminase (SGPT) and a decrease in glucose-6-phosphatase were observed upon treatment with pulegone.
Pretreatment of rats with phenobarbital (PB) or diethylmaleate (DEM) potentiated the hepatotoxicity caused by pulegone, whereas, pretreatment with 3-methylcholanthrene (3-MC) or piperonyl butoxide protected from it.
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