| Name | NADH dehydrogenase |
|---|---|
| Synonyms | B14.5b; NADH dehydrogenase; CI B14.5b; Complex I B14.5b; HLC 2; HLC2; NADH dehydrogenase [ubiquinone] 1 subunit C2; NADH ubiquinone oxidoreductase subunit B14.5b… |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1933335 | Pai KS, Ravindranath V: Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices. Brain Res. 1991 Aug 2;555(2):239-44. Exposure of sagittal slices of mouse brain to MPTP (100 pM) caused inhibition of mitochondrial NADH-dehydrogenase activity. Other cytochrome P-450 inhibitors, namely, piperonyl butoxide and SKF 525A were found to offer protection against MPTP induced neurotoxicity in slices without affecting monoamine oxidase activity. |
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| 7861152 | Sriram K, Pai KS, Ravindranath V: Protection and potentiation of 1-methyl-4-phenylpyridinium-induced toxicity by cytochrome P450 inhibitors and inducer may be due to the altered uptake of the toxin. J Neurochem. 1995 Mar;64(3):1203-8. Incubation of mouse brain slices with various concentrations of MPP+ (1-100 microM) resulted in dose-dependent inhibition of mitochondrial enzyme NADH-dehydrogenase -DH) and leakage of the cytosolic enzyme lactate dehydrogenase from the slice into the medium. MPP (+)-induced toxicity was abolished by pretreatment of the slices with inhibitors of monoamine oxidase (MAO; pargyline and deprenyl) or inhibitors of P450 (piperonyl butoxide or SKF-525A) or uptake blocker (GBR-12909), as measured by the activity of -DH in slices and leakage of lactate dehydrogenase from the slice into the medium. |
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| 9215992 | Sriram K, Boyd MR, Vistica DT, Ravindranath R: In vitro neurotoxicity of the antitumor agent 9-methoxy-N2-methylellipticinium (MMEA): role of brain cytochrome P-450. Neurotoxicology. 1997;18(1):97-104. However, other subcellular marker enzymes such as Na (+)-K+ATPase (plasma membrane), cytochrome c oxidase, isocitrate dehydrogenase, NADH-dehydrogenase (mitochondrial), N-acetylglucosaminidase, acid (lysosomal), glyceraldehyde-3-phosphate dehydrogenase and enolase (glycolytic enzymes) were unaffected even at the highest tested concentrations of MMEA (10 and 100 microM). Pretreatment of slices with piperonyl butoxide and inhibitor of cytochrome P-450, also prevented the toxicity of MMEA. |
1(0,0,0,1) | Details |