Protein Information

Name G protein coupled receptors
Synonyms ASRT 2; ASRT2; G protein coupled receptor 154; G protein coupled receptor for asthma susceptibility; G protein coupled receptor; G protein coupled receptor PGR14; GPR154; GPRA…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
20018167 Feng JJ, Cheng FC, Lin CH, Wei JW, Yang SD: Discovery and characterization of [3H] 8-OH-DPAT binding to HeLaS3 cells. Arch Biochem Biophys. 2010 Mar 1;495(1):14-20. Epub 2009 Dec 16.


Some G protein-coupled receptors (GPCRs) have functional links to cancer biology, yet the manifestation of GPCRs in tumor types is little studied to date.
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19493424 Zhang L, Zheng XM, Hubert J, Zheng H, Yang ZW, Li SW: Prenatal exposure to diaethylstilbestrol in the rat inhibits transabdominal testicular descent with involvement of the INSL3/LGR8 system and HOXA10. Chin Med J. 2009 Apr 20;122(8):967-71.


The mRNA expression of INSL3 and SF-1 in the testis and leucine rich repeat-containing G protein-coupled receptors 8 (LGR8) and homeobox-A10 (HOXA10) in the gubernaculum were determined by RT-PCR.
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17445746 Shukla AK, Haase W, Reinhart C, Michel H: Heterologous expression and comparative characterization of the human neuromedin U subtype II receptor using the methylotrophic yeast Pichia pastoris and mammalian cells. Int J Biochem Cell Biol. 2007;39(5):931-42. Epub 2007 Jan 24.


The physiological actions of NmU are mediated via two recently identified G protein-coupled receptors namely the neuromedin U type 1 receptor (NmU (1) R) and the neuromedin U type 2 receptor (NmU (2) R).
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19604106 Hong Y, Liu L, Pai S, Graf JN, Rao H, Lynn JG, van Staden C, Lee PH, Lai F, Salon JA: Development of multiplexed microarray binding assays for high-throughput drug discovery. Assay Drug Dev Technol. 2009 Jun;7(3):281-93.


Working towards this end, we report here the development of a microarray-based ligand binding assay that supports multiplexed analysis of G protein-coupled receptor systems in a 96-well microplate format that is compatible with the equipment and infrastructure typical of high-throughput screening laboratories.
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17337170 Li X, Shen F, Zhang Y, Zhu J, Huang L, Shi Q: Functional characterization of cell lines for high-throughput screening of human neuromedin U receptor subtype 2 specific agonists using a luciferase reporter gene assay. Eur J Pharm Biopharm. 2007 Aug;67(1):284-92. Epub 2007 Jan 23.


We describe in detail a robust, sensitive, and functional assay for the hNMU2R G-protein-coupled receptor expressed in human embryonic kidney (HEK)-293 cells, whose activity was reflected by a luciferase reporter gene transcriptionally regulated by a 3-repeat serum response element (SRE)-3 repeat multiple response element (MRE)-3 repeat cyclic AMP (cAMP) response element (CRE)-VIP mini promoter.
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18598671 Xia H, Liu L, Reinhart C, Michel H: Heterologous expression of human Neuromedin U receptor 1 and its subsequent solubilization and purification. Biochim Biophys Acta. 2008 Oct;1778(10):2203-9. Epub 2008 Jun 13.


Human Neuromedin U receptor 1 (hNmU-R1) is a member of G protein-coupled receptor family.
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19339661 Fricks IP, Carter RL, Lazarowski ER, Harden TK: Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8. Epub 2009 Apr 1.


Eight G protein-coupled receptors comprise the P2Y receptor family of cell signaling proteins.
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