| Name | WAF1 |
|---|---|
| Synonyms | CAP20; CDKN1A; Cip1; PIC 1; PIC1; P21; CDK interacting protein 1; CDK interaction protein 1… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17679552 | Kim YK: TGF-beta1 induction of p21WAF1/cip1 requires smad-independent protein kinase C signaling pathway. Arch Pharm Res. 2007 Jun;30(6):739-42. Although it has been demonstrated that p21WAF1/Cip1 could be induced by transforming growth factor-beta1 (TGF-beta1) in a Smad-dependent manner, the cross-talk of Smad signaling pathway with other signaling pathways still remains poorly understood. |
5(0,0,0,5) | Details |
| 17408467 | Alcantara O, Boldt DH: deprivation blocks multilineage haematopoietic differentiation by inhibiting induction of p21 (WAF1/CIP1). Br J Haematol. 2007 May;137(3):252-61. |
4(0,0,0,4) | Details |
| 18299943 | Deming D, Geiger P, Chen H, Vaccaro A, Kunnimalaiyaan M, Holen K: ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line. J Gastrointest Surg. 2008 May;12(5):852-7. Western blot analysis was performed to examine the activation of the Raf-1/mitogen-activated protein kinase kinase/ERK pathway, chromogranin A production, and p21CIP1 level. |
2(0,0,0,2) | Details |
| 18563491 | Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H: Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma. Ann Surg Oncol. 2008 Sep;15(9):2600-5. Epub 2008 Jun 18. Importantly, SBHA treatment resulted in an increase in protein levels of p21 (CIP1/WAF1), p27 (KIP1), cleaved caspase-9, cleaved caspase-3, and cleaved poly ADP- polymerase and concomitant with a decrease in cyclin D1 and cyclin B1, indicating that the growth inhibition was due to both cell cycle arrest and apoptosis. |
1(0,0,0,1) | Details |
| 17427960 | Chen H, Yang S, Yang Z, Ma L, Jiang D, Mao J, Jiao B, Cai Z: Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. J Cell Biochem. 2007 Dec 1;102(5):1281-9. Consequently, the inhibition of GSK-3beta decreased the nuclear factor-kappaB activity, the NF-kappaB-dependent gene expression, and COX2 expression, but enhanced p21 (WAF1/Cip1) transcription. |
2(0,0,0,2) | Details |
| 18555493 | Horiguchi A, Asano T, Asano T, Ito K, Sumitomo M, Hayakawa M: Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells. J Urol. 2008 Aug;180(2):729-36. Epub 2008 Jun 13. C75 suppressed Her2 and epidermal growth factor receptor expression as well as STAT3 phosphorylation, while increasing p53 and p21 (Waf1/Cip1) expression. |
1(0,0,0,1) | Details |