Protein Information

Name calmodulin
Synonyms CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18275158 Carruthers NJ, Stemmer PM: Methionine oxidation in the calmodulin-binding domain of calcineurin disrupts calmodulin binding and calcineurin activation. Biochemistry. 2007 Dec 11;46(49):14153-61. Epub 2007 Nov 13.

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19231837 Balog EM, Lockamy EL, Thomas DD, Ferrington DA: Site-specific methionine oxidation initiates calmodulin degradation by the 20S proteasome. Biochemistry. 2007 Sep 18;46(37):10498-505. Epub 2007 Aug 21.

This strategy of site-directed mutagenesis permitted site-selective oxidation of Met to Met sulfoxide.
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17711305 Smallwood HS, Lourette NM, Boschek CB, Bigelow DJ, Smith RD, Pasa-Tolic L, Squier TC: Identification of a denitrase activity against calmodulin in activated macrophages using high-field liquid chromatography--FTICR mass spectrometry. Curr Signal Transduct Ther. 2009 Jan 1;4(1):46-50.

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17997579 Chen B, Markillie LM, Xiong Y, Mayer MU, Squier TC: Increased catalytic efficiency following gene fusion of bifunctional methionine sulfoxide reductase enzymes from Shewanella oneidensis. Biochemistry. 2009 Apr 7;48(13):3005-16.


MsrBA is able to completely reduce (i.e., repair) MetSO in the calcium regulatory protein calmodulin (CaM), while only partial repair is observed using both MsrA and MsrB enzymes together at 25 degrees C.
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19823697 Agbas A, Moskovitz J: The Role of Methionine Oxidation/Reduction in the Regulation of Immune Response. table of contents.


This review will focus on two potential protein targets for methionine oxidation involved in signal transduction of the immune response: Ca (2+)/calmodulin-regulated phosphatase calcineurin (Cn) and inhibitor of kappa B-alpha (IkBalpha).
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18042863 Jones TL, Lustig AC, Sorkin LS: Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation. Anesth Analg. 2007 Dec;105(6):1650-6


In the present study, we investigated whether spinal calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) mediates 1 degree and/or 2 degrees hyperalgesia and spontaneous pain behavior after plantar incision.
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