Protein Information

Name thrombin
Synonyms Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18088485 Zhou J, Liu JH, Jin Y, Ouyang XL, Yang LG: [Protective effects of DMSO on function of lyophilized human platelets] . Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Dec;15(6):1284-8.


After pre-treatment for lyophilization, the expression of platelet membrane surface glycoprotein (GP) including CD62p and PAC-1 was analyzed by FCM before and after induction with thrombin, the mean platelet volume (MPV) and platelet maximal aggregation with several platelet inducers were investigated.
3(0,0,0,3) Details
19175732 Appleman EH, Sachais BS, Patel R, Drobatz KJ, Groman RP, Kennedy DR, O'Donnell PA, Bryan C, Callan MB: Cryopreservation of canine platelets. . J Vet Intern Med. 2009 Jan-Feb;23(1):138-45.


Cryopreserved platelets could be activated, as based on mean thrombin-stimulated P-selectin expression (6% DMSO, 23.0%; Thrombosol, 18.4%), although to a lesser extent than fresh PC (49.1%) (P < .0001).
1(0,0,0,1) Details
17493358 Yang HY, Tian W, Guo Y, Zhang RL, Zhang WG: [Experimental study on cryopreservation of platelets] . Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Apr;15(2):408-11.


The study was purposed to develop a novel cryopreserved agent (CPA) for platelets, to investigate the morphology of cryopreserved platelets in different CPA and the CD62P expression on membrane of platelets after stimulating by thrombin, as well as to compare the effect of adding UDP-Gal on preserved efficiency of preservation solutions.
1(0,0,0,1) Details
19338267 Sandblad P, Arnell R, Samuelsson J, Fornstedt T: Approach for reliable evaluation of drug proteins interactions using surface plasmon resonance technology. Anal Chem. 2009 May 1;81(9):3551-9.


The binding of the enantiomers of the thrombin inhibitor melagatran was investigated on both thrombin and the transport proteins, revealing clear enantioselectivity for thrombin in favor of the active enantiomer, but almost similar binding properties for both enantiomers to the transport protein AGP.
1(0,0,0,1) Details