Protein Information

Name GATA 4
Synonyms GATA binding factor 4; GATA binding protein 4; GATA 4; GATA4; Transcription factor GATA 4; GATA binding protein 4s; Transcription factor GATA 4s

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
17520663 Wen J, Xia Q, Lu C, Yin L, Hu J, Gong Y, Yin B, Monzen K, Yuan J, Qiang B, Zhang X, Peng X: Proteomic analysis of cardiomyocytes differentiation in mouse embryonic carcinoma P19CL6 cells. J Cell Biochem. 2007 Sep 1;102(1):149-60.


We demonstrated that P19CL6 cells indeed differentiated into cardiomyocytes after DMSO inducement as they expressed sarcomeric myosin heavy chain (MHC) as well as three cardiac-specific transcription factors (Csx/Nkx-2.5, GATA-4, and MEF2C).
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19585175 Gianakopoulos PJ, Skerjanc IS: Cross talk between hedgehog and bone morphogenetic proteins occurs during cardiomyogenesis in P19 cells. In Vitro Cell Dev Biol Anim. 2009 Oct;45(9):566-72. Epub 2009 Jul 8.


However, loss of Hh signaling resulted in a delay of BMP-4, GATA-4, Gli2, and Meox1 expression during cardiomyogenesis.
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19785986 Zhuo L, Gong J, Yang R, Sheng Y, Zhou L, Kong X, Cao K: Inhibition of proliferation and differentiation and promotion of apoptosis by cyclin L2 in mouse embryonic carcinoma P19 cells. Biochem Biophys Res Commun. 2009 Dec 18;390(3):451-7. Epub 2009 Sep 26.


Our data showed that stable CCNL2-overexpressing P19 cells were less differentiated after treatment with 1% DMSO and that expression of myocardial cell differentiation-related genes (such as cardiac actin, GATA4, Mef2C, Nkx2.5, and BNP) were reduced compared to vector-only transfected P19.
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19878064 Koninckx R, Hensen K, Daniels A, Moreels M, Lambrichts I, Jongen H, Clijsters C, Mees U, Steels P, Hendrikx M, Rummens JL: Human bone marrow stem cells co-cultured with neonatal rat cardiomyocytes display limited cardiomyogenic plasticity. Cytotherapy. 2009;11(6):778-92.


RESULTS: Co-culturing MSC induced expression of troponin T and GATA-4.
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19949579 Yang J, Ko SJ, Kim BS, Kim HS, Park S, Hong D, Hong SW, Choi JH, Park CY, Choi SC, Hong SJ, Lim DS: Enhanced cardiomyogenic differentiation of p19 embryonal carcinoma stem cells. Korean Circ J. 2009 May;39(5):198-204. Epub 2009 May 28.


RESULTS: Quantitative real-time polymerase chain reaction (PCR) analysis showed that the messenger ribonucleic acid (mRNA) expression of cardiac muscle-specific genes, such as GATA4, alpha-actin, alpha-myosin heavy chain, and cardiac troponin T, were significantly higher in the 15-day culture groups than in the 10-day culture groups.
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