| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19049974 | Maity P, Bindu S, Dey S, Goyal M, Alam A, Pal C, Mitra K, Bandyopadhyay U: Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation. J Biol Chem. 2009 Jan 30;284(5):3058-68. Epub 2008 Dec 2. The scavengers also restore indomethacin-induced activation of caspase-9 and caspase-3 to block mitochondrial pathway of apoptosis and gastric mucosal damage. |
1(0,0,0,1) | Details |
| 19576214 | Budd S, Byfield G, Martiniuk D, Geisen P, Hartnett ME: Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP. Exp Eye Res. 2009 Nov;89(5):718-27. Epub 2009 Jul 1. Cryosections or fresh tissue were analyzed for phospho-VEGFR1, phospho-VEGFR2, activated caspase-3, or phospho-beta3 integrin. |
1(0,0,0,1) | Details |
| 18563491 | Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H: Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma. Ann Surg Oncol. 2008 Sep;15(9):2600-5. Epub 2008 Jun 18. Importantly, SBHA treatment resulted in an increase in protein levels of p21 (CIP1/WAF1), p27 (KIP1), cleaved caspase-9, cleaved caspase-3, and cleaved poly ADP- polymerase and concomitant with a decrease in cyclin D1 and cyclin B1, indicating that the growth inhibition was due to both cell cycle arrest and apoptosis. |
1(0,0,0,1) | Details |
| 20101028 | Shimotake J, Derugin N, Wendland M, Vexler ZS, Ferriero DM: Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke. Stroke. 2010 Feb;41(2):343-9. Furthermore, receptor inhibition was associated with increased VEGFR2 expression 5 days after injury (P <0.05) and increased spectrin cleavage with a shift in favor of the calpain-mediated, caspase-3-independent cleavage (P <0.01). |
1(0,0,0,1) | Details |
| 19782097 | Datta S, Mazumder S, Ghosh D, Dey S, Bhattacharya S: Low concentration of arsenic could induce caspase-3 mediated head kidney macrophage apoptosis with JNK-p38 activation in Clarias batrachus. Toxicol Appl Pharmacol. 2009 Dec 15;241(3):329-38. Epub 2009 Sep 24. |
3(0,0,0,3) | Details |
| 18586875 | Sharma A, Neekhra A, Gramajo AL, Patil J, Chwa M, Kuppermann BD, Kenney MC: Effects of Benzo (e) Pyrene, a toxic component of cigarette smoke, on human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):5111-7. Epub 2008 Jun 27. Activities of caspase-3/7, caspase-8, caspase-9, and caspase-12 were measured by a fluorescence image scanner, and DNA laddering was evaluated by electrophoresis on 3% agarose gel. |
2(0,0,0,2) | Details |
| 18364113 | Yan JH, Yang XM, Chen CH, Hu Q, Zhao J, Shi XZ, Luan LJ, Yang L, Qin LH, Zhou CM: Pifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat. Chin Med J. 2008 Mar 5;121(5):414-9. METHODS: Male Sprague-Dawley rats weighing 300-350 g were randomly divided into five groups: a control group (sham surgery), a SAH group, a SAH+dimethyl sulfoxide (DMSO) group, a SAH + PFT-alpha (0.2 mg/kg) group and a SAH + PFT-alpha (2.0 mg/kg) group. Western blot and immunohistochemical staining were used to detect the levels of p53, PUMA and caspase-3 protein. |
2(0,0,0,2) | Details |
| 19224685 | Zhang M, Zhu LJ, Jia ZY, Xiao Y, Ju L, Zhang X: [Chrysotile fibers induced apoptosis of human bronchial epithelial cells and effect of oxidation]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Jan;27(1):11-5. METHODS: The cell survival rate, the morphological variation of BEAS-2B cells, the apoptosis rate, the expression levels of gene caspase-3 and the ROS generation level were measured by using trypan blue phagocytosis, hematoxylin and eosin staining, oligonucleosomal DNA fragmentation assay, FCM, RT-PCR and fluorescent probe DCFH-DA in the suspension (0, 5, 10, 20, 100 and 200 microg/cm (2)) and the filtrate (0, 100, 200, 400, 800 and 1600 microg/ml) of chrysotile fibers. |
2(0,0,0,2) | Details |
| 18593248 | Kisseberth WC, Murahari S, London CA, Kulp SK, Chen CS: Evaluation of the effects of histone deacetylase inhibitors on cells from canine cancer cell lines. Am J Vet Res. 2008 Jul;69(7):938-45. Apoptosis was assessed via ELISA to detect fragmentation of cytoplasmic nucleosomal DNA and western blot analysis to detect cleavage of caspase 3. |
2(0,0,0,2) | Details |
| 20091771 | Sribnick EA, Samantaray S, Das A, Smith J, Matzelle DD, Ray SK, Banik NL: Postinjury treatment of chronic spinal cord injury improves locomotor function in rats. J Neurosci Res. 2010 Jan 20. treatment reduced COX-2 activity, blocked nuclear factor-kappaB translocation, prevented glial reactivity, attenuated neuron death, inhibited activation and activity of calpain and caspase-3, decreased axonal damage, reduced myelin loss in the lesion and penumbra, and improved locomotor function compared with vehicle-treated animals. |
1(0,0,0,1) | Details |
| 17525209 | Perche O, Doly M, Ranchon-Cole I: Caspase-dependent apoptosis in light-induced retinal degeneration. . Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2753-9. Caspase-1, caspase-3, and calpain activities were measured before and 1 day after exposure to the damaging light. |
1(0,0,0,1) | Details |
| 19012662 | Martin-Renedo J, Mauriz JL, Jorquera F, Ruiz-Andres O, Gonzalez P, Gonzalez-Gallego J: induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res. 2008 Nov;45(4):532-40. Furthermore, treatment induced apoptosis with increased caspase-3 activity and poly (ADP- polymerase proteolysis. |
1(0,0,0,1) | Details |
| 18207679 | Qi W, Ding D, Salvi RJ: Cytotoxic effects of (DMSO) on cochlear organotypic cultures. Hear Res. 2008 Feb;236(1-2):52-60. Epub 2007 Dec 15. DMSO treatment induced TUNEL-positive staining in many hair cells and activated both initiator caspase-9 and caspase-8 and executioner caspase-3; this suggests that apoptosis is initiated by both intrinsic mitochondrial and extrinsic membrane cell death signaling pathways. |
1(0,0,0,1) | Details |
| 17532791 | Chen C, Hu Q, Yan J, Lei J, Qin L, Shi X, Luan L, Yang L, Wang K, Han J, Nanda A, Zhou C: Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1alpha and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model. J Neurochem. 2007 Sep;102(6):1831-41. Epub 2007 May 26. At 24 h, 2ME2 and D609 reduce the levels of HIF-1alpha and VEGF (enzyme-linked immunosorbent assay), depress the expression of HIF-1alpha, VEGF, BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) and cleaved caspase 3 (western blot and immunohistochemistry) in the brain infarct area. |
1(0,0,0,1) | Details |