| Name | mitogen activated protein kinase (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17892505 | Bell JR, Eaton P, Shattock MJ: Role of p38-mitogen-activated protein kinase in ischaemic preconditioning in rat heart. Clin Exp Pharmacol Physiol. 2008 Feb;35(2):126-34. Epub 2007 Sep 24. |
9(0,0,0,9) | Details |
| 17388918 | Meier F, Busch S, Lasithiotakis K, Kulms D, Garbe C, Maczey E, Herlyn M, Schittek B: Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. Br J Dermatol. 2007 Jun;156(6):1204-13. Epub 2007 Mar 28. |
7(0,0,0,7) | Details |
| 19436652 | Vikman P, Xu CB, Edvinsson L: Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Vasc Health Risk Manag. 2009;5(1):333-41. Epub 2009 Apr 8. In addition, the activity of three mitogen-activated protein kinases (p38, ERK 1/2 and SAPK/JNK) and their downstream transcription factors (ATF-2, Elk-1 and c-Jun) were examined. |
3(0,0,0,3) | Details |
| 17344341 | Kammerer B, Scheible H, Albrecht W, Gleiter CH, Laufer S: Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H--4-yl]-pyridin-2-yl}-( 1-phenylethyl)-amine), a 4-Pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor. Drug Metab Dispos. 2007 Jun;35(6):875-83. Epub 2007 Mar 7. In addition, pharmacokinetics of ML3403 were evaluated in male and female Wistar rats after oral gavage, showing a fast and high conversion to its active sulfoxide metabolite ML3603. |
3(0,0,0,3) | Details |
| 17395177 | Kishioka T, Iida C, Fujii K, Nagae R, Onishi Y, Ichi I, Kojo S: Effect of on oxidative stress, activation of mitogen activated protein kinase and necrosis caused by thioacetamide in the rat liver. Eur J Pharmacol. 2007 Jun 14;564(1-3):190-5. Epub 2007 Mar 12. |
2(0,0,0,2) | Details |
| 17382630 | Lu K, Cho CL, Liang CL, Chen SD, Liliang PC, Wang SY, Chen HJ: Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin-1-beta expression in spinal cord ischemia/reperfusion injury in rats. J Thorac Cardiovasc Surg. 2007 Apr;133(4):934-41. In the U0126-treated group, rats were pretreated with a specific inhibitor of the mitogen-activated protein kinase/extracellular signal-regulated kinases 1 and 2, U0126, to inhibit extracellular signal-regulated kinases 1 and 2 phosphorylation. |
2(0,0,0,2) | Details |
| 19012662 | Martin-Renedo J, Mauriz JL, Jorquera F, Ruiz-Andres O, Gonzalez P, Gonzalez-Gallego J: induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res. 2008 Nov;45(4):532-40. In this study, we examined the effect of administration on HepG2 human hepatocarcinoma cells, analyzing cell cycle arrest, apoptosis and mitogen-activated protein kinase (MAPK) signalling pathways. |
2(0,0,0,2) | Details |
| 20193422 | Qiu XM, Liu Y, Cong J, Wu XK: [Regulation of synthesis function of porcine ovarian granulose cells by mitogen-activated protein kinase signaling pathway.]. Zhonghua Fu Chan Ke Za Zhi. 2009 Dec;44(12):933-5. OBJECTIVE: To investigate the role of mitogen-activated protein kinase (MAPK) signaling pathway regulating synthesis function of steroid hormone of porcine ovarian granulose cells. |
2(0,0,0,2) | Details |
| 20084046 | Omori K, Todorov I, Shintaku J, Rawson J, Al-Abdullah IH, Higgins LS, Medicherla S, Kandeel F, Mullen Y: P38alpha-Selective Mitogen-Activated Protein Kinase Inhibitor for Improvement of Cultured Human Islet Recovery. Pancreas. 2010 Jan 13. |
2(0,0,0,2) | Details |
| 19726282 | Chen CL, Li TP, Zhu LH: [Effect of MAPK signal transduction pathway inhibitor U0126 on aquaporin 4 expression in alveolar type II cells in rats with -induced acute lung injury]. Nan Fang Yi Ke Da Xue Xue Bao. 2009 Aug;29(8):1525-8. |
1(0,0,0,1) | Details |
| 18699726 | Johnston PA, Soares KM, Shinde SN, Foster CA, Shun TY, Takyi HK, Wipf P, Lazo JS: Development of a 384-well colorimetric assay to quantify peroxide generated by the redox cycling of compounds in the presence of reducing agents. Assay Drug Dev Technol. 2008 Aug;6(4):505-18. Five of the mitogen-activated protein kinase phosphatase (MKP) 1 inhibitors identified in an HTS were shown to generate H (2) O (2) in the presence of DTT, and their inhibition of MKP-1 activity was shown to be time dependent and was abolished or significantly reduced by either 100 U of catalase or by higher DTT levels. |
1(0,0,0,1) | Details |
| 18005266 | Ratthe C, Girard D: Investigation of the interleukin (IL)-4/IL-4 receptor system in promyelocytic leukaemia PLB-985 cells during differentiation toward neutrophil-like phenotype: mechanism involved in IL-4-induced SOCS3 protein expression. Br J Haematol. 2008 Jan;140(1):59-70. Epub 2007 Nov 12. Moreover, PLB-985 cells lost surface expression of IL-13Ralpha1 during differentiation, resulting in PLB-985D cells expressing only IL-4Ralpha fully responsive to IL-4, as judged by activation of mitogen-activated protein (MAP) kinases and Janus kinase 1. |
1(0,0,0,1) | Details |
| 19339661 | Fricks IP, Carter RL, Lazarowski ER, Harden TK: Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8. Epub 2009 Apr 1. The effect of P2Y (14)-R activation on mitogen-activated protein kinase signaling also was studied in P2Y (14)-HEK293 cells and in differentiated HL-60 human myeloid leukemia cells. |
1(0,0,0,1) | Details |
| 19782097 | Datta S, Mazumder S, Ghosh D, Dey S, Bhattacharya S: Low concentration of arsenic could induce caspase-3 mediated head kidney macrophage apoptosis with JNK-p38 activation in Clarias batrachus. Toxicol Appl Pharmacol. 2009 Dec 15;241(3):329-38. Epub 2009 Sep 24. Exposure of HKM to arsenic induced the activation of mitogen-activated protein kinase family (MAPK) proteins including c-Jun NH (2)-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase (p38). |
1(0,0,0,1) | Details |
| 18645497 | Ito T, Omori K, Rawson J, Todorov I, Asari S, Kuroda A, Shintaku J, Itakura S, Ferreri K, Kandeel F, Mullen Y: Improvement of canine islet yield by donor pancreas infusion with a p38MAPK inhibitor. Transplantation. 2008 Jul 27;86(2):321-9. BACKGROUND: The activation of p38 mitogen-activated protein kinases (MAPK) is implicated in cold ischemia-reperfusion injury of donor organs. |
1(0,0,0,1) | Details |
| 18622691 | Davison Z, Dutkowski C, Gee JM, Nicholson RI, Heard CM: In vitro effects on MCF-7 breast cancer cells of signal transduction inhibitor/tamoxifen/ combinations and their simultaneous delivery across skin. Pharm Res. 2008 Nov;25(11):2516-25. Epub 2008 Jul 12. Immunocytochemical detection of phospho-MAPK, phospho-Akt, total COX-2 and Ki-67 was performed. |
1(0,0,0,1) | Details |
| 20091890 | Hui C, Like W, Yan F, Tian X, Qiuyan W, Lifeng H: S-allyl- sulfoxide inhibits tumor necrosis factor-alpha induced monocyte adhesion and intercellular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. Anat Rec. 2010 Mar;293(3):421-30. Apparently, ACSO inhibited proinflammatory cytokine-induced adhesion of monocytes to endothelial cells by inhibiting the mitogen-activated protein kinase signaling and related intercellular cell adhesion molecule-1 expression, maintaining mitochondrial membrane potential, and suppressing the overproduction of in endothelial cells. |
1(0,0,0,1) | Details |
| 18299943 | Deming D, Geiger P, Chen H, Vaccaro A, Kunnimalaiyaan M, Holen K: ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line. J Gastrointest Surg. 2008 May;12(5):852-7. Western blot analysis was performed to examine the activation of the Raf-1/mitogen-activated protein kinase kinase/ERK pathway, chromogranin A production, and p21CIP1 level. |
1(0,0,0,1) | Details |