Protein Information

Name P19
Synonyms CDK inhibitor p19INK4D; P19; CDKN2D; Cell cycle inhibitor Nur77 associating protein; Cyclin dependent kinase 4 inhibitor 2D; Cyclin dependent kinase 4 inhibitor D p19; Cyclin dependent kinase inhibitor 2D p19 inhibits CDK4; Cyclin dependent kinase 4 inhibitor D…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
19785986 Zhuo L, Gong J, Yang R, Sheng Y, Zhou L, Kong X, Cao K: Inhibition of proliferation and differentiation and promotion of apoptosis by cyclin L2 in mouse embryonic carcinoma P19 cells. Biochem Biophys Res Commun. 2009 Dec 18;390(3):451-7. Epub 2009 Sep 26.

6(0,0,0,6) Details
19949579 Yang J, Ko SJ, Kim BS, Kim HS, Park S, Hong D, Hong SW, Choi JH, Park CY, Choi SC, Hong SJ, Lim DS: Enhanced cardiomyogenic differentiation of p19 embryonal carcinoma stem cells. Korean Circ J. 2009 May;39(5):198-204. Epub 2009 May 28.


BACKGROUND AND OBJECTIVES: We investigated the effects of different concentrations of serum, 5-azacytidine, and culture time on the cardiomyogenic differentiation of P19 embryonal carcinoma stem cells in the course of developing an efficient protocol for generating the cardiomyogenic lineage.
5(0,0,0,5) Details
18317697 Choi SC, Choi JH, Shim WJ, Lim DS: P19 embryonal carcinoma cells: a new model for the study of endothelial cell differentiation. Biotechnol Lett. 2008 Jul;30(7):1169-75. Epub 2008 Mar 4.

4(0,0,0,4) Details
19149193 Lei L, Dou L, Yan L, Dou Z, Wang H: [Effect of NHE1 on stem cell differentiation into cardiomyocytes] . Sheng Wu Gong Cheng Xue Bao. 2008 Oct;24(10):1790-5.


To study the effect of NHE1 activity in stem cells differentiation into cardiomyocytes, we treated P19 stem cells with dimethyl sulfoxide (DMSO) to initiate cardiomyocyte differentiation.
4(0,0,0,4) Details
19585175 Gianakopoulos PJ, Skerjanc IS: Cross talk between hedgehog and bone morphogenetic proteins occurs during cardiomyogenesis in P19 cells. In Vitro Cell Dev Biol Anim. 2009 Oct;45(9):566-72. Epub 2009 Jul 8.

3(0,0,0,3) Details
19814781 Kennedy KA, Porter T, Mehta V, Ryan SD, Price F, Peshdary V, Karamboulas C, Savage J, Drysdale TA, Li SC, Bennett SA, Skerjanc IS: Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin. BMC Biol. 2009 Oct 8;7:67.


Thus, the purpose of this study is to examine the molecular mechanisms by which RA enhances skeletal myogenesis and interacts with Wnt and BMP4 signalling during P19 or mouse embryonic stem (ES) cell differentiation.
3(0,0,0,3) Details
17520663 Wen J, Xia Q, Lu C, Yin L, Hu J, Gong Y, Yin B, Monzen K, Yuan J, Qiang B, Zhang X, Peng X: Proteomic analysis of cardiomyocytes differentiation in mouse embryonic carcinoma P19CL6 cells. J Cell Biochem. 2007 Sep 1;102(1):149-60.


A clonal derivative named P19CL6 has been isolated from pluripotent P19 mouse embryonic carcinoma cells, and this subline efficiently differentiates into beating cardiomyocytes when treated with 1% dimethyl sulfoxide (DMSO).
1(0,0,0,1) Details
18538425 Fathi F, Murasawa S, Hasegawa S, Asahara T, Kermani AJ, Mowla SJ: Cardiac differentiation of P19CL6 cells by oxytocin. . Int J Cardiol. 2009 May 1;134(1):75-81. Epub 2008 Jun 5.


BACKGROUND: It has been reported that P19 embryonal carcinoma (EC) cells differentiate into beating cardiomyocytes under the action of oxytocin (OT).
1(0,0,0,1) Details