Protein Information

Name erythropoietin
Synonyms EP; EPO; Epoetin; Erythropoietin; Erythropoietin precursor; Epoetins; Erythropoietins; Erythropoietin precursors

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
19347245 Scher W, Jing Y, Lu M, Bishop DF, Scher BM: Sequences of polycythemia-type Friend spleen focus-forming virus in clone-745-derived mouse erythroleukemia cells. Arch Virol. 2009;154(5):895-8. Epub 2009 Apr 4.


Mice infected with the original Friend virus isolates were anemic, so sub-lines derived from these mice should be erythropoietin-dependent for induction of erythrodifferentiation.
3(0,0,0,3) Details
18661870 Labrenz SR, Calmann MA, Heavner GA, Tolman G: The oxidation of methionine-54 of epoetinum alfa does not affect molecular structure or stability, but does decrease biological activity. PDA J Pharm Sci Technol. 2008 May-Jun;62(3):211-23.

Erythropoietin therapy is used to treat severe anemia in renal failure and chemotherapy patients.
We have observed partial and full chemical oxidation of methionine-54 to methionine-54 sulfoxide, accomplished using tert-Butylhydroperoxide and hydrogen peroxide, respectively.
2(0,0,0,2) Details
20008515 DeNiro M, Al-Halafi A, Al-Mohanna FH, Alsmadi O, Al-Mohanna FA: Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. Mol Pharmacol. 2010 Mar;77(3):348-67. Epub 2009 Dec 14.


Furthermore, YC-1 down-regulated VEGF, erythropoietin, endothelin-1, matrix metalloproteinase-9, and iNOS message and protein levels.
1(0,0,0,1) Details
19327822 Murua A, Orive G, Hernandez RM, Pedraz JL: Cryopreservation based on freezing protocols for the long-term storage of microencapsulated myoblasts. Biomaterials. 2009 Jul;30(20):3495-501. Epub 2009 Mar 27.


In the present paper, alginate-poly-l-lysine-alginate (APA) microcapsules containing erythropoietin (Epo)-secreting C (2) C (12) myoblasts were elaborated, characterized and tested both in vitro and in vivo.
1(0,0,0,1) Details
19659677 Migliaccio G, Sanchez M, Leblanc A, Masiello F, Tirelli V, Migliaccio AR, Najfeld V, Whitsett C: Long-term storage does not alter functionality of in vitro generated human erythroblasts: implications for ex vivo generated erythroid transfusion products. Transfusion. 2009 Dec;49(12):2668-79. Epub 2009 Jul 29.


STUDY DESIGN AND METHODS: Using mononuclear cells from four adult blood donors, erythroblasts were generated ex vivo in expansion cultures supplemented with stem cell factor, interleukin-3, erythropoietin (EPO), dexamethasone, and estradiol.
1(0,0,0,1) Details
18336085 Binder C, Lafayette A, Archibeque I, Sun Y, Plewa C, Sinclair A, Emkey R: Optimization and utilization of the SureFire phospho-STAT5 assay for a cell-based screening campaign. Assay Drug Dev Technol. 2008 Feb;6(1):27-37.


STAT5 is phosphorylated by several JAKs, including Jak3, Jak2, and Tyk2, in response to interleukin-2, erythropoietin (EPO), and interleukin-22, respectively.
1(0,0,0,1) Details