| Name | human ether a go go related gene |
|---|---|
| Synonyms | HERG; Voltage gated potassium channel; ERG; ERG1; Eag homolog; Eag related protein 1; Ether a go go related gene potassium channel 1; Ether a go go related protein 1… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18957172 | Crumb W, Benyamina A, Arbus C, Thomas GP, Garay RP, Hameg A: Cyamemazine metabolites: effects on human cardiac ion channels in-vitro and on the QTc interval in guinea pigs. J Pharm Pharmacol. 2008 Nov;60(11):1507-13. Monodesmethyl cyamemazine and cyamemazine sulfoxide, the two main metabolites of the antipsychotic and anxiolytic phenothiazine cyamemazine, were investigated for their effects on the human ether-a-go-go related gene (hERG) channel expressed in HEK 293 cells and on native I (Na), I (Ca), I (to), I (sus) or I (K1) of human atrial myocytes. |
81(1,1,1,1) | Details |
| 19583963 | Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W: A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Anal Biochem. 2009 Nov 1;394(1):30-8. Epub 2009 Jul 5. |
7(0,0,0,7) | Details |
| 17624316 | Su Z, Limberis J, Martin RL, Xu R, Kolbe K, Heinemann SH, Hoshi T, Cox BF, Gintant GA: Functional consequences of oxidation of hERG channels. Biochem Pharmacol. 2007 Sep 1;74(5):702-11. Epub 2007 Jun 7. Functional consequences of oxidative modification of in human ether a go-go related gene 1 (hERG1), which encodes cardiac I (Kr) channels, are unknown. |
2(0,0,0,2) | Details |
| 17590357 | Himmel HM: Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG current and on rabbit Purkinje fiber action potential. J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):145-58. Epub 2007 May 24. METHODS: Excipients were tested for potential interference with the hERG (human ether-a-go-go-related gene) K (+) current (whole-cell voltage-clamp, 23+/-2 degrees C), and the shape of rabbit Purkinje fiber action potentials (conventional glass microelectrode technique, 37+/-1 degrees C). |
1(0,0,0,1) | Details |