Protein Information

Name PPAR delta
Synonyms FAAR; NR1C2; NUC 1; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; PPAR beta…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
17878286 Yu YH, Wu SC, Cheng WT, Mersmann HJ, Ding ST: Ectopic expression of porcine peroxisome proliferator-activated receptor delta regulates adipogenesis in mouse myoblasts. J Anim Sci. 2008 Jan;86(1):64-72. Epub 2007 Sep 18.

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19237170 Minutoli L, Antonuccio P, Polito F, Bitto A, Squadrito F, Irrera N, Nicotina PA, Fazzari C, Montalto AS, Di Stefano V, Romeo C, Altavilla D: Peroxisome proliferator activated receptor beta/delta activation prevents extracellular regulated kinase 1/2 phosphorylation and protects the testis from ischemia and reperfusion injury. J Urol. 2009 Apr;181(4):1913-21. Epub 2009 Feb 23.


PPARbeta/delta is expressed in testis and its role is largely unknown.
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20167109 Galuppo M, Di Paola R, Mazzon E, Genovese T, Crisafulli C, Paterniti I, Cuzzocrea E, Bramanti P, Kapoor A, Thiemermann C, Cuzzocrea S: Role of PPAR-delta in the development of zymosan-induced multiple organ failure: an experiment mice study. J Inflamm. 2010 Feb 18;7:12.

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19946680 Thevis M, Moller I, Thomas A, Beuck S, Rodchenkov G, Bornatsch W, Geyer H, Schanzer W: Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls. Anal Bioanal Chem. 2010 Apr;396(7):2479-91. Epub 2009 Nov 28.

These allowed the identification and characterization of mono-oxygenated and bisoxygenated metabolites (sulfoxide and sulfone, respectively) as supported by high-resolution/high-accuracy mass spectrometry with higher-energy collision-induced dissociation, tandem mass spectrometry, and nuclear magnetic resonance spectroscopy.
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