Protein Information

Name thioredoxin reductase
Synonyms ACR 1; PLP; ACR1; AOEB166; Alu corepressor 1; Antioxidant enzyme B166; B166; Liver tissue 2D page spot 71B…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
19406205 Hondal RJ: Using chemical approaches to study selenoproteins-focus on thioredoxin reductases. Biochim Biophys Acta. 2009 Nov;1790(11):1501-12. Epub 2009 May 4.

3(0,0,0,3) Details
19958171 Ugarte N, Petropoulos I, Friguet B: Oxidized Mitochondrial Protein Degradation and Repair in Aging and Oxidative Stress. Antioxid Redox Signal. 2010 Mar 8.


Oxidized protein repair systems, thioredoxin/thioredoxin reductase or glutaredoxin/glutathione/glutathione reductase that catalytically reduce disulfide bridges or sulfenic acids, and methionine sulfoxide reductase that reverses methionine sulfoxide back to methionine within proteins, are present in the mitochondrial matrix.
1(0,0,0,1) Details
17364942 Moskovitz J: Prolonged selenium-deficient diet in MsrA knockout mice causes enhanced oxidative modification to proteins and affects the levels of antioxidant enzymes in a tissue-specific manner. Free Radic Res. 2007 Feb;41(2):162-71.


More specifically, the SD diet caused alteration in the expression and/or activities of certain antioxidants as follows: lowering the specific activity of MsrB in the MsrA -/- cerebellum in comparison to WT mice; lowering the activities of glutathione peroxidase (Gpx) and thioredoxin reductase (Trr) especially in brains of MsrA -/- mice; elevation of the cellular levels of selenoprotein P (SelP) in most tissues of the MsrA -/- relative to WT.
1(0,0,0,1) Details
18581249 Vinokur V, Grinberg L, Berenshtein E, Gross M, Moskovitz J, Reznick AZ, Chevion M, Eliashar R: Methionine-centered redox cycle in organs of the aero-digestive tract of young and old rats. Biogerontology. 2009 Feb;10(1):43-52. Epub 2008 Jun 26.


The levels of cytosolic thioredoxin (Trx), thioredoxin reductase (TrxR), and methionine sulfoxide reductase (Msr), all tended to decline with age.
1(0,0,0,1) Details
18667555 Atack JM, Kelly DJ: Contribution of the stereospecific methionine sulphoxide reductases MsrA and MsrB to oxidative and nitrosative stress resistance in the food-borne pathogen Campylobacter jejuni. Microbiology. 2008 Aug;154(Pt 8):2219-30.


Cj0637 and Cj1112 were overexpressed, purified and shown by a coupled thioredoxin-thioredoxin reductase-NADPH assay to catalyse the stereospecific reduction of the S and R diastereoisomers, respectively, of the model compound methyl p-tolyl sulphoxide.
1(0,0,0,1) Details
20306235 Hawkes WC, Alkan Z: Regulation of Redox Signaling by Selenoproteins. Biol Trace Elem Res. 2010 Mar 20.


Thioredoxin reductases (three genes) use nicotinamide adenine dinucleotide phosphate to reduce oxidized thioredoxin and its homologs, which regulate a plethora of redox signaling events.
1(0,0,0,1) Details
19146434 Shaik N, Martinez A, Augustin I, Giovinazzo H, Varela-Ramirez A, Sanau M, Aguilera RJ, Contel M: Synthesis of Apoptosis-Inducing Iminophosphorane Organogold (III) Complexes and Study of Their Interactions with Biomolecular Targets. Inorg Chem. 2009 Feb 16;48(4):1577-87.


The interaction of 2 with two model proteins (cytochrome c and thioredoxin reductase) has been analyzed by spectroscopic methods (vis-UV and fluorescence).
1(0,0,0,1) Details