Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
20024146 Peterson JR, Smith TA, Thordarson P: Synthesis and room temperature photo-induced electron transfer in biologically active bis (terpyridine) ruthenium (II)-cytochrome c bioconjugates and the effect of solvents on the bioconjugation of cytochrome c. Org Biomol Chem. 2010 Jan 7;8(1):151-62. Epub 2009 Nov 16.

8(0,0,0,8) Details
18555026 Thariat J, Collin F, Marchetti C, Ahmed-Adrar NS, Vitrac H, Jore D, Gardes-Albert M: Marked difference in cytochrome c oxidation mediated by HO (*) and/or O (2)(*-) free radicals in vitro. Biochimie. 2008 Oct;90(10):1442-51. Epub 2008 May 27.

5(0,0,0,5) Details
19461988 Brennan LA, Lee W, Cowell T, Giblin F, Kantorow M: Deletion of mouse MsrA results in HBO-induced cataract: MsrA repairs mitochondrial cytochrome c. Mol Vis. 2009 May 15;15:985-99.

3(0,0,0,3) Details
17532618 Ji X, Ren J, Jin J, Nakamura T: A sensor for superoxide in aqueous and organic/aqueous media based on immobilized cytochrome c on binary self-assembled monolayers. Biosens Bioelectron. 2007 Sep 30;23(2):241-7. Epub 2007 Apr 19.

2(0,0,0,2) Details
19934869 Stumpner J, Redel A, Kellermann A, Lotz CA, Blomeyer CA, Smul TM, Kehl F, Roewer N, Lange M: Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction. Anesthesiology. 2009 Dec;111(6):1257-64.


Protein expression of Pim-1 kinase, Bad, phospho-Bad, and cytosolic content of cytochrome c were measured using Western immunoblotting.
2(0,0,0,2) Details
17680283 Casini A, Mastrobuoni G, Terenghi M, Gabbiani C, Monzani E, Moneti G, Casella L, Messori L: Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium (III) complex imidazolium trans-[tetrachloro (dimethyl sulfoxide)(imidazole) ruthenate (III)] with hen egg white lysozyme and horse heart cytochrome c. J Biol Inorg Chem. 2007 Nov;12(8):1107-17. Epub 2007 Aug 7.

2(0,0,0,2) Details
19114548 Wu H, Soler-Garcia AA, Jerse AE: A strain-specific catalase mutation and mutation of the metal-binding transporter gene mntC attenuate Neisseria gonorrhoeae in vivo but not by increasing susceptibility to oxidative killing by phagocytes. Infect Immun. 2009 Mar;77(3):1091-102. Epub 2008 Dec 29.


Here we showed that a gonococcal catalase (kat) mutant in strain MS11 was more sensitive to H (2) O (2) than mutants in cytochrome c peroxidase (ccp), methionine sulfoxide reductase (msrA), or the metal-binding protein (mntC) of the MntABC transporter. kat ccp and kat ccp mntC mutants were significantly more sensitive to H (2) O (2) than mutants in any single factor.
1(0,0,0,1) Details
17880209 Liu GF, Filipovic M, Heinemann FW, Ivanovic-Burmazovic I: Seven-coordinate iron and manganese complexes with acyclic and rigid pentadentate chelates and their superoxide dismutase activity. Inorg Chem. 2007 Oct 15;46(21):8825-35. Epub 2007 Sep 20.


The cytochrome c McCord-Fridovich (McCF) assay in an aqueous solution at pH = 7.8 resulted in the IC (50) values (and corresponding kMcCF constants) for 3 and 4, 0.013 +/- 0.001 microM (1.9 +/- 0.2 x 10 (8) M (-1) s (-1)) and 0.024 +/- 0.001 microM (1.1 +/- 0.3 x 10 (8) M (-1) s (-1)), respectively.
1(0,0,0,1) Details
19012662 Martin-Renedo J, Mauriz JL, Jorquera F, Ruiz-Andres O, Gonzalez P, Gonzalez-Gallego J: Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res. 2008 Nov;45(4):532-40.


Proapoptotic effects of melatonin were related to cytosolic cytochrome c release, upregulation of Bax and induction of caspase-9 activity.
1(0,0,0,1) Details
19146434 Shaik N, Martinez A, Augustin I, Giovinazzo H, Varela-Ramirez A, Sanau M, Aguilera RJ, Contel M: Synthesis of Apoptosis-Inducing Iminophosphorane Organogold (III) Complexes and Study of Their Interactions with Biomolecular Targets. Inorg Chem. 2009 Feb 16;48(4):1577-87.


The interaction of 2 with two model proteins (cytochrome c and thioredoxin reductase) has been analyzed by spectroscopic methods (vis-UV and fluorescence).
1(0,0,0,1) Details