| 17761204 |
Fried KW, Bazzi R, Levy Lopez W, Corsten C, Schramm KW, Bell DR, Rozman KK: Relationship between aryl hydrocarbon receptor-affinity and the induction of EROD activity by 2,3,7,8-tetrachlorinated phenothiazine and derivatives. Toxicol Appl Pharmacol. 2007 Oct 15;224(2):147-55. Epub 2007 Jul 19.
Reported herein are semi-empirical calculations of the molecular geometry of TCDD, TCPT, TCPT-sulfoxide (TCPT-O), TCPT-sulfone (TCPT-O (2)), N-methyl-TCPT (Me-TCPT), N-methyl-TCPT-sulfoxide (Me-TCPT-O), and N-methyl-TCPT-sulfone (Me-TCPT-O (2)), the characterization of their AhR binding affinity in rat hepatic cytosol, and their ability to induce EROD activity in a rat hepatoma cell line in vitro. |
38(0,1,1,8) |
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