Protein Information

Name IL 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
19237170 Minutoli L, Antonuccio P, Polito F, Bitto A, Squadrito F, Irrera N, Nicotina PA, Fazzari C, Montalto AS, Di Stefano V, Romeo C, Altavilla D: Peroxisome proliferator activated receptor beta/delta activation prevents extracellular regulated kinase 1/2 phosphorylation and protects the testis from ischemia and reperfusion injury. J Urol. 2009 Apr;181(4):1913-21. Epub 2009 Feb 23.


We evaluated testicular extracellular signal regulated kinase, tumor necrosis factor-alpha and interleukin-6 by Western blot.
3(0,0,0,3) Details
19966493 Saegusa S, Totsuka M, Kaminogawa S, Hosoi T: Saccharomyces cerevisiae and Candida albicans stimulate cytokine secretion from human neutrophil-like HL-60 cells differentiated with retinoic acid or dimethylsulfoxide. Biosci Biotechnol Biochem. 2009 Dec;73(12):2600-8. Epub 2009 Dec 7.


Intact and heat-killed S. cerevisiae enhanced secretion of interleukin (IL)-1beta, IL-6, IL-8, IL-12, IL-18, MCP-1/CCL2 and TNF-alpha from retinoic acid-treated HL-60 cells, accompanied by alterations in mRNA expression of the cytokines.
2(0,0,0,2) Details
19678539 Zimecki M, Artym J, Cisowski W, Mazol I, Wlodarczyk M, Glensk M: Immunomodulatory and anti-inflammatory activity of selected osthole derivatives. Z Naturforsch C. 2009 May-Jun;64(5-6):361-8.


The compounds were also tested for their activity on tumour necrosis factor a and interleukin 6 production, induced by lipopolysaccharide, in cultures of rat peritoneal cells and human peripheral blood mononuclear cells.
2(0,0,0,2) Details
19436652 Vikman P, Xu CB, Edvinsson L: Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Vasc Health Risk Manag. 2009;5(1):333-41. Epub 2009 Apr 8.


The expression of matrix metalloproteinase 9 and 13 (MMP9 and MMP13), angiotensin receptor 1 and 2 (AT (1) and AT (2)), interleukin 6 and inducible nitric oxide synthase (iNOS) were investigated at mRNA level by real-time PCR and/or at protein level by immunohistochemistry.
1(0,0,0,1) Details
17603938 Pradeepkumar Singh L, Kundu P, Ganguly K, Mishra A, Swarnakar S: Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer. Free Radic Biol Med. 2007 Jul 15;43(2):289-99. Epub 2007 Apr 29.


Increased secretion of proMMP-9 was associated with increased expression of tumor necrosis factor-alpha and interleukin-6.
1(0,0,0,1) Details
19878061 Akkok CA, Liseth K, Hervig T, Ryningen A, Bruserud O, Ersvaer E: Use of different DMSO concentrations for cryopreservation of autologous peripheral blood stem cell grafts does not have any major impact on levels of leukocyte- and platelet-derived soluble mediators. Cytotherapy. 2009;11(6):749-60.


Low or undetectable levels of leukocyte-derived interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha and CXCL8, high levels of platelet-derived CCL5 and CXCL4, and high levels of monocyte-derived soluble CD14 were measured independent of the DMSO concentration, except for slightly increased CXCL8 and decreased CXCL4 levels with 2% DMSO.
1(0,0,0,1) Details
19551541 Akkok CA, Liseth K, Hervig T, Ryningen A, Bruserud O, Ersvaer E: Use of different DMSO concentrations for cryopreservation of autologous peripheral blood stem cell grafts does not have any major impact on levels of leukocyte- and platelet-derived soluble mediators. Cytotherapy. 2009 Jun 23:1-12.


Low or undetectable levels of leukocyte-derived intereukin (IL)-6 and tumor necrosis factor (TNF)-alpha and CXCL8, high levels of platelet-derived CCL5 and CXCL4, and high levels of monocyte-derived soluble CD14 were measured independent of the DMSO concentration, except for slightly increased CXCL8 and decreased CXCL4 levels with 2% DMSO.
1(0,0,0,1) Details
19336900 Kim YH, Kim DH, Lim H, Baek DY, Shin HK, Kim JK: The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biol Pharm Bull. 2009 Apr;32(4):651-6.


Furthermore, the levels of interleukin-6 and tumor necrosis factor-alpha were decreased by MSM treatment in cell culture supernatants.
1(0,0,0,1) Details
18457866 Saito M, Watanabe S: Differential modulation of lipopolysaccharide- and zymosan-induced hypophagia by dexamethasone treatment. Pharmacol Biochem Behav. 2008 Sep;90(3):428-33. Epub 2008 Apr 4.


The attenuated response was associated with the suppression of the gene induction of proinflammatory cytokines (i.e., IL-1beta, IL-6 and TNFalpha) in the brain and liver.
1(0,0,0,1) Details
19474210 Liu Y, Shi J, Lu J, Meng G, Zhu H, Hou Y, Yin Y, Zhao S, Ding B: Activation of peroxisome proliferator-activated receptor-gamma potentiates pro-inflammatory cytokine production, and adrenal and somatotropic changes of weaned pigs after Escherichia coli lipopolysaccharide challenge. Innate Immun. 2009 Jun;15(3):169-78.


Rather, plasma levels of tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6), mRNA abundance of TNF-a in thymus, spleen, mesenteric lymph node and peripheral white blood cells, mRNA abundance of IL-6 in thymus, protein levels of TNF-a in spleen and mesenteric lymph node, and protein levels of IL-6 in spleen and mesenteric lymph node, were elevated beyond the levels in control pigs injected with LPS.
1(0,0,0,1) Details
17725367 Chu Y, Deng H, Cheng JP: An acidity scale of 1,3-dialkylimidazolium salts in dimethyl sulfoxide solution. J Org Chem. 2007 Sep 28;72(20):7790-3. Epub 2007 Aug 29.


The pKa values were observed to range from 23.4 for IL 12 to 19.7 for IL 6 (Tables 1 and 2), responding mainly to structural variations on the cation moiety.
1(0,0,0,1) Details
20084046 Omori K, Todorov I, Shintaku J, Rawson J, Al-Abdullah IH, Higgins LS, Medicherla S, Kandeel F, Mullen Y: P38alpha-Selective Mitogen-Activated Protein Kinase Inhibitor for Improvement of Cultured Human Islet Recovery. Pancreas. 2010 Jan 13.


Interleukin 6 mRNA expression in cultured islets, as well as IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor released into the medium, was significantly reduced by adding SD-282.
1(0,0,0,1) Details