| Name | cytochrome P450 1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17344101 | Mortensen AS, Arukwe A: Modulation of xenobiotic biotransformation system and hormonal responses in Atlantic salmon (Salmo salar) after exposure to tributyltin (TBT). Comp Biochem Physiol C Toxicol Pharmacol. 2007 Apr;145(3):431-41. Epub 2007 Feb 2. The expression of CYP1A1 and GST showed a TBT concentration-dependent decrease. |
2(0,0,0,2) | Details |
| 19494032 | Jenny MJ, Karchner SI, Franks DG, Woodin BR, Stegeman JJ, Hahn ME: Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2009 Aug;110(2):426-41. Epub 2009 Jun 3. The aryl hydrocarbon receptor (AHR) repressor (AHRR), an AHR-related basic helix-loop-helix/Per-AHR nuclear translocator-Sim protein, is regulated by an AHR-dependent mechanism and acts as a transcriptional repressor of AHR function. |
2(0,0,0,2) | Details |
| 19497421 | Vondracek J, Krcmar P, Prochazkova J, Trilecova L, Gavelova M, Skalova L, Szotakova B, Buncek M, Radilova H, Kozubik A, Machala M: The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells. Chem Biol Interact. 2009 Jul 15;180(2):226-37. Epub 2009 Mar 27. We report here that, apart from induction of CYP1A1 and CYP1B1 expression and the corresponding enzymatic activity, both BaP and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced rat 3alpha-hydroxysteroid dehydrogenase (AKR1C9) expression and activity. |
2(0,0,0,2) | Details |
| 19219915 | Grondin M, Hamel F, Averill-Bates DA, Sarhan F: Wheat proteins improve cryopreservation of rat hepatocytes. . Biotechnol Bioeng. 2009 Jun 15;103(3):582-91. These improved procedures enhance long-term storage (2-12 months) and recovery of large quantities of healthy cells after cryopreservation, and maintain the differentiated functions of rat hepatocytes, compared to freshly isolated cells, as judged by viability (77-93%), adherence (77%) and metabolic functions of major cytochrome P450 isoforms CYP1A1/2, CYP2C6, CYP2D2, and CYP3A1/2. |
1(0,0,0,1) | Details |
| 17875331 | Mortensen AS, Arukwe A: Effects of 17alpha- on hormonal responses and xenobiotic biotransformation system of Atlantic salmon (Salmo salar). Aquat Toxicol. 2007 Nov 30;85(2):113-23. Epub 2007 Aug 17. The effect of EE2 on the CYP1A1 gene expressions paralleled effect on EROD and AhRR mRNA, suggesting a direct role of EE2 in controlling cellular detoxification machinery. |
1(0,0,0,1) | Details |
| 19280519 | Choi S, Sainz B Jr, Corcoran P, Uprichard S, Jeong H: Characterization of increased drug metabolism activity in (DMSO)-treated Huh7 hepatoma cells. Xenobiotica. 2009 Mar;39(3):205-17. Additionally, treatment of the Huh7 cells with 3-methylcholanthrene induced cytochrome P450 (CYP) 1A1 expression. |
1(0,0,0,1) | Details |
| 20090406 | Neis MM, Wendel A, Wiederholt T, Marquardt Y, Joussen S, Baron JM, Merk HF: Expression and induction of cytochrome p450 isoenzymes in human skin equivalents. Skin Pharmacol Physiol. 2010;23(1):29-39. Epub 2010 Jan 14. The expression of CYP1A1 and CYP1B1 was highly inducible by treatment with liquor carbonis detergens. |
1(0,0,0,1) | Details |
| 19684285 | Kim S, Dere E, Burgoon LD, Chang CC, Zacharewski TR: Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells. Toxicol Sci. 2009 Nov;112(1):229-44. Epub 2009 Aug 14. Most genes exhibited dose-dependent responses including CYP1A1, CYP1B1, ALDH1A3, and SLC7A5 genes. |
1(0,0,0,1) | Details |
| 20104500 | Terry C, Dhawan A, Mitry RR, Lehec SC, Hughes RD: Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation. Liver Transpl. 2010 Feb;16(2):229-37. The effects on thawed cell viability and attachment, lactate dehydrogenase release, cytochrome P450 1A1/2 activity, and albumin synthesis were determined. |
1(0,0,0,1) | Details |
| 18617602 | Grondin M, Hamel F, Sarhan F, Averill-Bates DA: Metabolic activity of cytochrome p450 isoforms in hepatocytes cryopreserved with wheat protein extract. Drug Metab Dispos. 2008 Oct;36(10):2121-9. Epub 2008 Jul 10. This was achieved by comparing basal and inducible or metabolic activities of isoforms CYP1A1, CYP1A2, CYP2C6, CYP2D2, and CYP3A in rat hepatocytes that were cryopreserved with WPE, relative to fresh cells and those cryopreserved with DMSO. |
1(0,0,0,1) | Details |
| 18373956 | Arukwe A, Nordbo B: Hepatic biotransformation responses in Atlantic salmon exposed to retinoic acids and 3,3',4,4'-tetrachlorobiphenyl (PCB congener 77). Comp Biochem Physiol C Toxicol Pharmacol. 2008 May;147(4):470-82. Epub 2008 Feb 19. Liver samples collected from all exposure groups were analyzed for gene (RARalpha, AhR2alpha, AhR2beta, CYP1A1, UGT1 and GSTpi) expression using real-time PCR and activity (7-ethoxyresorufin O-deethylase (EROD), UGT and GST) using biochemical methods with specific substrates. |
4(0,0,0,4) | Details |