| Name | COX2 |
|---|---|
| Synonyms | COX 2; COX2; PHS2; PGG/HS; Cyclooxygenase 2; Cyclooxygenase 2b; Cycloxygenase 2; PGH synthase 2… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18349286 | Reid JM, Mandrekar SJ, Carlson EC, Harmsen WS, Green EM, McGovern RM, Szabo E, Ames MM, Boring D, Limburg PJ: Comparative bioavailability of sulindac in capsule and tablet formulations. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):674-9. The cyclooxygenase (COX)-2 enzyme appears to be an important target for cancer chemoprevention. Encapsulation of the parent compound (sulindac sulfoxide) can be readily accomplished, but the effects of alternate formulations on bioavailability have not been rigorously examined. |
1(0,0,0,1) | Details |
| 19693696 | Yar AS, Menevse S, Alp E, Helvacioglu F, Take G: The effects of on cyclooxygenase-1 and cyclooxygenase-2 mRNA and protein levels in diabetic rat kidneys. Mol Biol Rep. 2009 Aug 20. |
1(0,0,0,1) | Details |
| 17511027 | Seo SW, Jung WS, Piao TG, Hong SH, Yun KJ, Park RK, Shin MK, Song HJ, Park SJ: Selective cyclooxygenase-2 inhibitor ameliorates cholecystokinin-octapeptide-induced acute pancreatitis in rats. World J Gastroenterol. 2007 Apr 28;13(16):2298-304. |
1(0,0,0,1) | Details |
| 19336900 | Kim YH, Kim DH, Lim H, Baek DY, Shin HK, Kim JK: The anti-inflammatory effects of on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biol Pharm Bull. 2009 Apr;32(4):651-6. MSM significantly inhibited the release of and (2) by alleviating the expression of inducible synthase and cyclooxygenase-2 in LPS-stimulated RAW264.7 cells. |
1(0,0,0,1) | Details |
| 18484887 | Bandi G, Wilkinson EA, Cary-Coyle TL, Jerde TJ, Nakada SY: Third prize: Effect of on porcine ureteral contractility in vitro. J Endourol. 2008 Jun;22(6):1169-73. Corticosteroids inhibit the production of phospholipase A2 and cyclooxygenase-2, both of which are involved in prostaglandin synthesis. |
1(0,0,0,1) | Details |
| 17504133 | Dogne JM, Thiry A, Pratico D, Masereel B, Supuran CT: Dual carbonic anhydrase--cyclooxygenase-2 inhibitors. . Curr Top Med Chem. 2007;7(9):885-91. |
1(0,0,0,1) | Details |
| 17427960 | Chen H, Yang S, Yang Z, Ma L, Jiang D, Mao J, Jiao B, Cai Z: Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. J Cell Biochem. 2007 Dec 1;102(5):1281-9. Consequently, the inhibition of GSK-3beta decreased the nuclear factor-kappaB activity, the NF-kappaB-dependent gene expression, and COX2 expression, but enhanced p21 (WAF1/Cip1) transcription. |
1(0,0,0,1) | Details |
| 17451196 | Baek JY, Hur W, Wang JS, Bae SH, Yoon SK: Selective COX-2 inhibitor, NS-398, suppresses cellular proliferation in human hepatocellular carcinoma cell lines via cell cycle arrest. World J Gastroenterol. 2007 Feb 28;13(8):1175-81. AIM: To investigate the growth inhibitory mechanism of NS-398, a selective cyclooxygenase-2 (COX-2) inhibitor, in two hepatocellular carcinoma (HCC) cell lines (HepG2 and Huh7). |
1(0,0,0,1) | Details |
| 19152372 | Mulabagal V, Subbaraju GV, Rao CV, Sivaramakrishna C, Dewitt DL, Holmes D, Sung B, Aggarwal BB, Tsay HS, Nair MG: Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation. Phytother Res. 2009 Jul;23(7):987-92. |
0(0,0,0,0) | Details |