Protein Information

Name calcineurin (protein family or complex)
Synonyms Calcineurin; Calcineurins; Protein phosphatase 2B

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18275158 Carruthers NJ, Stemmer PM: Methionine oxidation in the calmodulin-binding domain of calcineurin disrupts calmodulin binding and calcineurin activation. Biochemistry. 2008 Mar 11;47(10):3085-95. Epub 2008 Feb 15.

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19823697 Agbas A, Moskovitz J: The Role of Methionine Oxidation/Reduction in the Regulation of Immune Response. Curr Signal Transduct Ther. 2009 Jan 1;4(1):46-50.


This review will focus on two potential protein targets for methionine oxidation involved in signal transduction of the immune response: Ca (2+)/calmodulin-regulated phosphatase calcineurin (Cn) and inhibitor of kappa B-alpha (IkBalpha).
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