Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
20104500 Terry C, Dhawan A, Mitry RR, Lehec SC, Hughes RD: Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation. Liver Transpl. 2010 Feb;16(2):229-37.


The effects on thawed cell viability and attachment, lactate dehydrogenase release, cytochrome P450 1A1/2 activity, and albumin synthesis were determined.
2(0,0,0,2) Details
19945446 Bergandi L, Aina V, Garetto S, Malavasi G, Aldieri E, Laurenti E, Matera L, Morterra C, Ghigo D: Fluoride-containing bioactive glasses inhibit pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human osteoblasts. Chem Biol Interact. 2010 Feb 12;183(3):405-15. Epub 2009 Nov 27.


A 24h incubation with 50 microg/ml (12.5 microg/cm (2)) of fluoride-containing bioactive glasses termed HCaCaF (2) (F content: 5, 10 and 15 mol.%) caused the release of lactate dehydrogenase in the extracellular medium (index of cytotoxicity), the accumulation of intracellular malonyldialdehyde (index of lipoperoxidation), and the increase of glutathione consumption.
1(0,0,0,1) Details
20029958 Tanwar V, Sachdeva J, Kishore K, Mittal R, Nag TC, Ray R, Kumari S, Arya DS: Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence. Cell Biochem Funct. 2010 Jan;28(1):74-82.


There was an increase in glutathione, superoxide dismutase (SOD), creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) levels, decrease in thiobarbituric acid reactive substances (TBARS), and preservation of myocardial architecture in the curcumin (100 and 200 mg/kg) treated groups.
1(0,0,0,1) Details
18273562 Mishra P, Kale RK, Kar A: Chemoprevention of mammary tumorigenesis and chemomodulation of the antioxidative enzymes and peroxidative damage in prepubertal Sprague Dawley rats by Biochanin A. Mol Cell Biochem. 2008 May;312(1-2):1-9. Epub 2008 Feb 14.


Spectrophotometric enzyme estimations revealed that the specific activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione transferase (GST), DT-diaphorase (DTD), and reduced glutathione (GSH) levels were increased, whereas specific activities of lactate dehydrogenase (LDH) and lipid peroxidation (LPO) were decreased significantly, both in liver as well as in mammary gland, in animals treated with Biochanin A prepubertally.
1(0,0,0,1) Details
18679782 Wang Z, Li M, Wu WK, Tan HM, Geng DF: Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of phosphatidylinositol-3-kinase signal transduction. Cardiovasc Drugs Ther. 2008 Dec;22(6):443-52. Epub 2008 Aug 5.


Plasma creatine kinase (CK), creatine kinase isoenzyme MB (CK-MB), lactate dehydrogenase (LDH), and troponin T levels were also measured.
1(0,0,0,1) Details
17803263 Doran JA, O'Donnell JS, Lairson LL, McDonald MR, Schwan AL, Grodzinski B: S-alk (en) yl-L-cysteine sulfoxides and relative pungency measurements of photosynthetic and nonphotosynthetic tissues of Allium porrum. J Agric Food Chem. 2007 Oct 3;55(20):8243-50. Epub 2007 Sep 6.

Background pyruvate levels varied depending on the assay used, ranging from 0.4 (lactate dehydrogenase) to 1.5 (high-performance liquid chromatography, HPLC) micromol g (-1) fresh weight (FW) on average.
Profiles were composed of (-/+)-methyl-, (-/+)-ethyl-, (+)-propyl-, and (+)-1-propenyl-L-cysteine sulfoxide (MCSO, ECSO, PCSO, and 1-PeCSO, respectively). (+)-PCSO was the most prominent in green (2.4 mg g (-1) FW), yellow (5.5 mg g (-1) FW), and white (3.8 mg g (-1) FW) tissues.
1(0,0,0,1) Details
17549591 Silva AR, Pinheiro AM, Souza CS, Freitas SR, Vasconcellos V, Freire SM, Velozo ES, Tardy M, El-Bacha RS, Costa MF, Costa SL: The flavonoid rutin induces astrocyte and microglia activation and regulates TNF-alpha and NO release in primary glial cell cultures. Cell Biol Toxicol. 2008 Jan;24(1):75-86. Epub 2007 Jun 5.


However, an increased lactate dehydrogenase activity was detected in the culture medium of both culture systems when treated with 100 micromol/L rutin, suggesting loss of cell membrane integrity.
1(0,0,0,1) Details
18197582 Zimmermann S, Zarse K, Schulz TJ, Siems K, Muller-Kuhrt L, Birringer M, Ristow M: A cell-based high-throughput assay system reveals modulation of oxidative and nonoxidative glucose metabolism due to commonly used organic solvents. Horm Metab Res. 2008 Jan;40(1):29-37.


D-Glucose uptake from the supernatant media was quantified by the glucose oxidase method, and L-lactate production of cells was quantified by the lactate dehydrogenase method applied on supernatant media.
1(0,0,0,1) Details