Protein Information

Name alcohol dehydrogenase (protein family or complex)
Synonyms ADH; alcohol dehydrogenase; alcohol dehydrogenases

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
17429946 Meijers R, Adolph HW, Dauter Z, Wilson KS, Lamzin VS, Cedergren-Zeppezauer ES: Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase. Biochemistry. 2007 May 8;46(18):5446-54. Epub 2007 Apr 13.

2(0,0,0,2) Details
18702138 Lavandera I, Kern A, Schaffenberger M, Gross J, Glieder A, de Wildeman S, Kroutil W: An exceptionally DMSO-tolerant alcohol dehydrogenase for the stereoselective reduction of ketones. ChemSusChem. 2008;1(5):431-6.

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19465532 Shainsky J, Derry NL, Leichtmann-Bardoogo Y, Wood TK, Fishman A: Rapid methods for high-throughput detection of sulfoxides. Appl Environ Microbiol. 2009 Jul;75(14):4711-9. Epub 2009 May 22.

Due to low sensitivity during whole-cell screening, this method was found to be useful only for determining the presence or absence of sulfoxide in the reaction.
The third method, selective inhibition of horse liver alcohol dehydrogenase, was used to rapidly screen highly active and/or enantioselective variants at position V106 of toluene ortho-monooxygenase in a saturation mutagenesis library, using methyl-p-tolyl sulfide as the substrate.
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