Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18811077 Jones DM, Fabian B, Kramer B: The effect of retinoic acid on mouse mandibular molar development in vitro, using alkaline phosphatase as a molecular indicator of differentiation. SADJ. 2008 Jun;63(5):276

5(0,0,0,5) Details
19576196 Yin H, Cui L, Liu G, Cen L, Cao Y: Vitreous cryopreservation of tissue engineered bone composed of bone marrow mesenchymal stem cells and partially demineralized bone matrix. 278-80.


The level of alkaline phosphatase (ALP) expression and osteocalcin (OCN) deposition in VS442 preserved TEB was also higher than those in the VS55 group since 3days post-rewarm.
1(0,0,0,1) Details
19726282 Chen CL, Li TP, Zhu LH: [Effect of MAPK signal transduction pathway inhibitor U0126 on aquaporin 4 expression in alveolar type II cells in rats with oleic acid-induced acute lung injury]. Nan Fang Yi Ke Da Xue Xue Bao. 2009 Aug;29(8):1525-8.


ATII cells were isolated from the lung tissues and identified using tannic acid staining and alkaline phosphatase (APK) staining.
1(0,0,0,1) Details
18495102 Liu G, Zhou H, Li Y, Li G, Cui L, Liu W, Cao Y: Evaluation of the viability and osteogenic differentiation of cryopreserved human adipose-derived stem cells. Cryobiology. 2008 Aug;57(1):18-24. Epub 2008 May 21.


To detect osteogenic differentiation of both the cryopreserved and non-cryopreserved populations, determination of osteoblastic protein production (alkaline phosphatase and osteocalcin) and excellular matrix calcification (calcium content) was applied.
1(0,0,0,1) Details
18836674 Still K, Grabowski P, Mackie I, Perry M, Bishop N: The peroxisome proliferator activator receptor alpha/delta agonists linoleic acid and bezafibrate upregulate osteoblast differentiation and induce periosteal bone formation in vivo. Calcif Tissue Int. 2008 Oct;83(4):285-92. Epub 2008 Oct 4.


PPARalpha/delta agonists increased significantly the number of osteoblastic colonies as demonstrated by increased alkaline phosphatase activity, collagen production, and calcification.
1(0,0,0,1) Details
19857481 Nishigaki T, Teramura Y, Suemori H, Iwata H: Cryopreservation of primate embryonic stem cells with chemically-defined solution without Me2SO. Cryobiology. 2010 Apr;60(2):159-64. Epub 2009 Oct 24.


After the cryopreservation and thawing cycle, hES cells were easily cultured and expressed undifferentiated cell markers such as Nanog, Oct-4, SSEA-4, and alkaline phosphatase activity after several subculturing steps.
1(0,0,0,1) Details
17443435 Zhang Y, Zeng X, Zhang L, Zheng X: Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts. Planta Med. 2007 Apr;73(4):341-7. Epub 2007 Apr 18.

DMEM:Dulbecco's modification of Eagel's medium PBS:phosphate buffered saline DMSO:dimethyl sulfoxide EDTA:ethylene diamine tetraacetic acid SDS:sodium dodecyl sulfate SDS-PAGE:sodium dodecylsulfate polyacrylamide gel electrophoresis FITC:fluorescein isothiocyanate HRP:horseradish peroxidase PI3K:phosphatidylinositol 3-kinase.
Data showed that puerarin caused a significant increase in cell viability, alkaline phosphatase (ALP) activity and mineral nodules formation in osteoblasts, suggesting that puerarin had a stimulatory effect on osteoblastic bone formation.
1(0,0,0,1) Details
18584890 Nishikawa H, Kodama E, Sakakibara A, Fukudome A, Izumi K, Oishi S, Fujii N, Matsuoka M: Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41. Cryobiology. 2009 Oct;59(2):180-7. Epub 2009 Jul 1.


One method uses an alkaline phosphatase (ALP)-conjugated antibody (Ab-ELISA) and the other uses an ALP-fused HR (F-ELISA) to detect and quantify the interaction of the two HRs.
1(0,0,0,1) Details