| Name | Tyrosinase |
|---|---|
| Synonyms | LB24 AB; Monophenol monooxygenase; OCA1A; OCAIA; SK29 AB; TYR; TYR protein; Tumor rejection antigen AB… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18293936 | Pievo R, Gullotti M, Monzani E, Casella L: Tyrosinase catalyzes asymmetric sulfoxidation. Biochemistry. 2008 Mar 18;47(11):3493-8. Epub 2008 Feb 23. An experiment using (18) O 2 showed that 18-O incorporation into methyl phenyl sulfoxide was above 95%, confirming that the mechanism of the sulfoxidation involves transfer from oxy-tyrosinase to the sulfide. |
84(1,1,1,4) | Details |
| 19672047 | Shuster V, Fishman A: Isolation, cloning and characterization of a tyrosinase with improved activity in organic solvents from Bacillus megaterium. J Mol Microbiol Biotechnol. 2009;17(4):188-200. Epub 2009 Aug 6. |
4(0,0,0,4) | Details |
| 18329644 | Luchs A, Sumida DH, Visconti MA, Castrucci AM: Biological effects of insulin on murine melanoma cells and fish erythrophoroma cells: a comparative study. Gen Comp Endocrinol. 2008 Apr 1;156(2):218-23. Epub 2008 Feb 12. In the two mammalian cell lines, and in DMSO-differentiated GEM-81 cells, the hormone strongly inhibited melanogenesis, by decreasing tyrosinase activity. |
1(0,0,0,1) | Details |
| 19237503 | Wood JM, Decker H, Hartmann H, Chavan B, Rokos H, Spencer JD, Hasse S, Thornton MJ, Shalbaf M, Paus R, Schallreuter KU: Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting repair. FASEB J. 2009 Jul;23(7):2065-75. Epub 2009 Feb 23. Accordingly, Met-S=O formation of Met residues, including Met 374 in the active site of tyrosinase, the key enzyme in melanogenesis, limits enzyme functionality, as evidenced by FT-Raman spectroscopy, computer simulation, and enzyme kinetics, which leads to gradual loss of hair color. |
1(0,0,0,1) | Details |