Protein Information

Name glucose 6 phosphate dehydrogenase
Synonyms 6 phosphogluconolactonase; GDH; G6PDH; Glucose 6 phosphate dehydrogenase; GDH/6PGL endoplasmic bifunctional protein; GDH/6PGL endoplasmic bifunctional protein precursor; Glucose 1 dehydrogenase; Glucose dehydrogenase…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
19945446 Bergandi L, Aina V, Garetto S, Malavasi G, Aldieri E, Laurenti E, Matera L, Morterra C, Ghigo D: Fluoride-containing bioactive glasses inhibit pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human osteoblasts. Chem Biol Interact. 2010 Feb 12;183(3):405-15. Epub 2009 Nov 27.

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17364942 Moskovitz J: Prolonged selenium-deficient diet in MsrA knockout mice causes enhanced oxidative modification to proteins and affects the levels of antioxidant enzymes in a tissue-specific manner. Free Radic Res. 2007 Feb;41(2):162-71.


Unexpectedly, the expression and activity of glucose-6-phosphate dehydrogenase (G6PD) were mainly elevated in lungs and hearts of MsrA -/- mice.
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19374864 Kalaiarasi P, Pugalendi KV: Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats. Eur J Pharmacol. 2009 Mar 15;606(1-3):269-73. Epub 2009 Jan 21.


Activities of gluconeogenic enzymes such as glucose 6-phosphatase, fructose 1, 6-bisphosphatase increased and glucokinase, glucose 6-phosphate dehydrogenase decreased in the liver along with glycogen.
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19680996 Izumo K, Horiuchi M, Komatsu M, Aoyama K, Bandow K, Matsuguchi T, Takeuchi M, Takeuchi T: Dehydroepiandrosterone increased oxidative stress in a human cell line during differentiation. Free Radic Res. 2009 Oct;43(10):922-31. Epub 2009 Aug 12.


Dehydroepiandrosterone (DHEA), a reversible inhibitor of glucose-6-phosphate dehydrogenase (G6PD), is increasingly taken as an antioxidative and anti-ageing supplement.
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