| Name | vascular endothelial growth factor |
|---|---|
| Synonyms | VEGF; VEGF A; VEGFA; VPF; Vascular endothelial growth factor A; Vascular endothelial growth factor A precursor; Vascular permeability factor; vascular endothelial growth factor… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18413228 | Peterson KJ, Sadowsky JD, Scheef EA, Pal S, Kourentzi KD, Willson RC, Bresnick EH, Sheibani N, Gellman SH: A fluorescence polarization assay for identifying ligands that bind to vascular endothelial growth factor. Anal Biochem. 2008 Jul 1;378(1):8-14. Epub 2008 Mar 28. |
6(0,0,0,6) | Details |
| 19342033 | Shah DK, Menon KM, Cabrera LM, Vahratian A, Kavoussi SK, Lebovic DI: Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro. Fertil Steril. 2010 Apr;93(6):2042-7. Epub 2009 Apr 1. |
5(0,0,0,5) | Details |
| 17532791 | Chen C, Hu Q, Yan J, Lei J, Qin L, Shi X, Luan L, Yang L, Wang K, Han J, Nanda A, Zhou C: Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1alpha and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model. J Neurochem. 2007 Sep;102(6):1831-41. Epub 2007 May 26. Despite (2ME2) and tricyclodecan-9-yl-xanthogenate (D609) having multiple effects on cancer cells, mechanistically, both of them down-regulate hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF). |
4(0,0,0,4) | Details |
| 20008515 | DeNiro M, Al-Halafi A, Al-Mohanna FH, Alsmadi O, Al-Mohanna FA: Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of -induced retinopathy. Mol Pharmacol. 2010 Mar;77(3):348-67. Epub 2009 Dec 14. Vascular endothelial growth factor (VEGF) and inducible synthase (iNOS) have been implicated in ischemia-induced retinal neovascularization. |
3(0,0,0,3) | Details |
| 18025837 | Yu WZ, Zou H, Li XX, Yan Z, Dong JQ: Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization. Ophthalmic Res. 2008;40(1):19-25. Epub 2007 Nov 20. METHODS: The effect of LY294002 on the survival of RF/6A cells stimulated by vascular endothelial growth factor (VEGF) was investigated colorimetrically. |
3(0,0,0,3) | Details |
| 18515580 | Koyama Y, Matsuzaki S, Gomi F, Yamada K, Katayama T, Sato K, Kumada T, Fukuda A, Matsuda S, Tano Y, Tohyama M: Induction of amyloid beta accumulation by ER disruption and resultant upregulation of angiogenic factors in ARPE19 cells. Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2376-83. Cellular expressions of both a series of Abeta metabolism-related factors and angiogenic factors were evaluated by real-time RT-PCR and Western blot (VEGF). |
2(0,0,0,2) | Details |
| 19576214 | Budd S, Byfield G, Martiniuk D, Geisen P, Hartnett ME: Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP. Exp Eye Res. 2009 Nov;89(5):718-27. Epub 2009 Jul 1. Human umbilical venous (HUVECs) and human choroidal endothelial cells (ECs) were treated with VEGFR2 inhibitor to determine effect on VEGFR2 phosphorylation and on directed EC migration toward a VEGF gradient. |
2(0,0,0,2) | Details |
| 20101028 | Shimotake J, Derugin N, Wendland M, Vexler ZS, Ferriero DM: Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke. Stroke. 2010 Feb;41(2):343-9. BACKGROUND AND PURPOSE: Recent studies in neonatal rodent stroke models suggest that recovery is due in part to upregulation of hypoxia-inducible factor-1-a and its downstream target, vascular endothelial growth factor. |
2(0,0,0,2) | Details |
| 18317697 | Choi SC, Choi JH, Shim WJ, Lim DS: P19 embryonal carcinoma cells: a new model for the study of endothelial cell differentiation. Biotechnol Lett. 2008 Jul;30(7):1169-75. Epub 2008 Mar 4. A prominent capillary-like network including PECAM-1 positive cells and upregulated expression of endothelial markers Tie-1, Tie-2, Flk-1 and PECAM-1 were identified in the DMSO-treated group during EB formation as well as after VEGF treatment. |
1(0,0,0,1) | Details |
| 18032914 | Song SJ, Chung H, Yu HG: Inhibitory effect of YC-1, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole, on experimental choroidal neovascularization in rat. Ophthalmic Res. 2008;40(1):35-40. Epub 2007 Nov 20. The expression of HIF-1alpha and vascular endothelial growth factor (VEGF) in CNV was evaluated by immunofluorescence staining. |
1(0,0,0,1) | Details |
| 19647313 | Oh EJ, Park K, Choi JS, Joo CK, Hahn SK: Synthesis, characterization, and preliminary assessment of anti-Flt1 peptide-hyaluronate conjugate for the treatment of corneal neovascularization. Biomaterials. 2009 Oct;30(30):6026-34. Epub 2009 Jul 31. According to in vitro biological activity tests, anti-Flt1 peptide-HA conjugate exhibited a significant inhibition effect on the binding of Flt1-Fc to VEGF (165) coated on the well. |
1(0,0,0,1) | Details |
| 20332449 | Pourgholami MH, Cai ZY, Chu SW, Galettis P, Morris DL: The influence of ovarian cancer induced peritoneal carcinomatosis on the pharmacokinetics of albendazole in nude mice. Anticancer Res. 2010 Feb;30(2):423-8. This may at least in part be attributed to the high vascular endothelial growth factor levels present in the peritoneal cavity of the diseased mice. The current study was designed to find the pharmacokinetics of the drug and its major metabolites albendazole sulfoxide (ABZSO) and albendazole sulfone (ABZSO (2)) in an experimental model of ovarian cancer. |
1(0,0,0,1) | Details |